STRINGSTRING
CELA1 CELA1 PRSS8 PRSS8 CELA2A CELA2A TMPRSS15 TMPRSS15 GZMB GZMB PLG PLG HABP2 HABP2 HPN HPN KLK1 KLK1 KLK14 KLK14 LOC110261434 LOC110261434 TMPRSS11A TMPRSS11A LOC100154047 LOC100154047 TMPRSS4 TMPRSS4 LOC100739735 LOC100739735 PRSS22 PRSS22 CFI CFI LOC100302368 LOC100302368 ST14 ST14 KLK7 KLK7 TMPRSS9 TMPRSS9 LOC100513671 LOC100513671 CORIN CORIN ACR ACR TMPRSS11E TMPRSS11E KLK6 KLK6 TMPRSS12 TMPRSS12 MCT7 MCT7 F11 F11 KLK5 KLK5 PRSS41 PRSS41 HGFAC HGFAC KLK8 KLK8 MASP2 MASP2 PROC PROC I3LP35_PIG I3LP35_PIG PRSS21 PRSS21 ELANE ELANE KLK4 KLK4 CTRL CTRL OVCH2 OVCH2 LOC100512727 LOC100512727 LOC100621820 LOC100621820 C1RL C1RL C2 C2 CTRC CTRC PLAT PLAT PRSS36 PRSS36 LOC396700 LOC396700 PRSS27 PRSS27 PRSS33 PRSS33 TMPRSS11D TMPRSS11D TMPRSS11F TMPRSS11F PRSS48 PRSS48 PRSS12 PRSS12 F10 F10 KLK15 KLK15 F7 F7 F1RJP7_PIG F1RJP7_PIG PLAU PLAU F1SNW5_PIG F1SNW5_PIG F9 F9 F2 F2 PRTN3 PRTN3 CFD CFD CTRB2 CTRB2 F12 F12 KLKB1 KLKB1 PRSS56 PRSS56 LOC110259104 LOC110259104 LOC100515176 LOC100515176 PRSS2 PRSS2 GZMK GZMK GZMA GZMA TMPRSS13 TMPRSS13 MASP1 MASP1 TMPRSS5 TMPRSS5 TMPRSS7 TMPRSS7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CELA1Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (257 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (344 aa)
CELA2AChymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (287 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
GZMBPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
HABP2Hyaluronan binding protein 2. (591 aa)
HPNHepsin; Belongs to the peptidase S1 family. (449 aa)
KLK1Glandular kallikrein; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (263 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (252 aa)
LOC110261434Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (420 aa)
LOC100154047Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
LOC100739735Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (338 aa)
CFIComplement factor I isoform 1 preproprotein; Belongs to the peptidase S1 family. (587 aa)
LOC100302368Trypsin. (246 aa)
ST14Suppressor of tumorigenicity 14 protein. (856 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (257 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1074 aa)
LOC100513671Transmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
CORINCorin, serine peptidase. (1113 aa)
ACRAcrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family. (414 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (422 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (246 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (366 aa)
MCT7Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. (275 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (295 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (314 aa)
HGFACHGF activator. (661 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa)
MASP2Uncharacterized protein; Belongs to the peptidase S1 family. (823 aa)
PROCVitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa)
I3LP35_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
PRSS21Serine protease 21; Belongs to the peptidase S1 family. (317 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
KLK4Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (566 aa)
LOC100512727Transmembrane protease serine; Belongs to the peptidase S1 family. (407 aa)
LOC100621820Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (588 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (853 aa)
CTRCChymotrypsin-C; Belongs to the peptidase S1 family. (268 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (855 aa)
LOC396700Tryptase beta-2 preproprotein; Belongs to the peptidase S1 family. (317 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (326 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (278 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (322 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
F10Uncharacterized protein. (536 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (260 aa)
F7Uncharacterized protein. (455 aa)
F1RJP7_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa)
F1SNW5_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (391 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (462 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (268 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
CTRB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa)
KLKB1Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (605 aa)
LOC110259104Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (429 aa)
LOC100515176Peptidase S1 domain-containing protein. (162 aa)
PRSS2Putative trypsinogen; Belongs to the peptidase S1 family. (247 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (526 aa)
MASP1Mannan-binding lectin serine protease 1 isoform 2; Belongs to the peptidase S1 family. (728 aa)
TMPRSS5Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (198 aa)
TMPRSS7Transmembrane serine protease 7; Belongs to the peptidase S1 family. (829 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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