STRINGSTRING
DAB2IP DAB2IP PKN3 PKN3 SYDE2 SYDE2 PLCG1 PLCG1 SNRNP200 SNRNP200 PRKCE PRKCE CC2D2A CC2D2A LOC100625564 LOC100625564 DOCK5 DOCK5 RASAL1 RASAL1 PTEN PTEN SYT2 SYT2 CPNE4 CPNE4 MTMR14 MTMR14 SYTL4 SYTL4 CAPN6 CAPN6 DOCK11 DOCK11 PLCB3 PLCB3 RASAL3 RASAL3 TNS2 TNS2 SYT9 SYT9 C2CD3 C2CD3 CAPN5 CAPN5 SYTL2 SYTL2 C2CD2L C2CD2L PIK3C2B PIK3C2B SYT14 SYT14 DOCK10 DOCK10 TNS3 TNS3 DOCK2 DOCK2 UNC13D UNC13D PRKCA PRKCA PLCD3 PLCD3 PLCD1 PLCD1 C2CD2 C2CD2 RASA4B RASA4B CPNE8 CPNE8 SYT8 SYT8 PLCD4 PLCD4 CC2D2B CC2D2B RIMS2 RIMS2 MCTP1 MCTP1 AIDA AIDA ESYT1 ESYT1 SMURF1 SMURF1 DYSF DYSF UNC13B UNC13B NEDD4L NEDD4L RAB11FIP5 RAB11FIP5 PLCB1 PLCB1 TNS1 TNS1 RIMS1 RIMS1 BAIAP3 BAIAP3 RPH3A RPH3A CC2D1A CC2D1A ITSN2 ITSN2 RASA1 RASA1 SYTL1 SYTL1 WWC1 WWC1 WWP1 WWP1 SYTL5 SYTL5 ABR ABR PLCB2 PLCB2 OTOF OTOF PLA2G4A PLA2G4A MYOF MYOF SYNGAP1 SYNGAP1 C2CD4C C2CD4C WWP2 WWP2 CC2D1B CC2D1B SYT12 SYT12 PIK3C2A PIK3C2A GAK GAK PIK3C2G PIK3C2G RIMS4 RIMS4 C2CD4D C2CD4D DOCK7 DOCK7 PKN2 PKN2 RPGRIP1L RPGRIP1L RASAL2 RASAL2 UVRAG UVRAG DNAJC6 DNAJC6 DOCK8 DOCK8 PRKCB PRKCB SYT4 SYT4 DOCK1 DOCK1 SYT10 SYT10 PLCZ1 PLCZ1 SYT1 SYT1 CCDC33 CCDC33 CPNE6 CPNE6 PLCB4 PLCB4 TOLLIP TOLLIP SYT6 SYT6 PLCH2 PLCH2 ASCC3 ASCC3 HECW1 HECW1 BCR BCR MCTP2 MCTP2 DOCK3 DOCK3 UNC13A UNC13A CPNE5 CPNE5 FER1L6 FER1L6 PIK3CG PIK3CG A0A287ASP1_PIG A0A287ASP1_PIG SMURF2 SMURF2 SYT13 SYT13 DOCK9 DOCK9 RAB11FIP1 RAB11FIP1 SYT7 SYT7 PKN1 PKN1 WWC2 WWC2 PRF1 PRF1 SYT11 SYT11 SYT17 SYT17 CPNE3 CPNE3 CEP120 CEP120 DOCK6 DOCK6 PLCL2 PLCL2 PIK3CB PIK3CB PIK3CA PIK3CA PLA2G4E PLA2G4E PRKCD PRKCD ESYT2 ESYT2 WWC3 WWC3 INPP4B INPP4B DOC2B DOC2B UNC13C UNC13C NEDD4 NEDD4 RAB11FIP2 RAB11FIP2 DOCK4 DOCK4 PLCH1 PLCH1 RPGRIP1 RPGRIP1 TC2N TC2N PLCG2 PLCG2 SYT3 SYT3 PRKCG PRKCG PIK3C3 PIK3C3 SYTL3 SYTL3 SEC63 SEC63 PLA2G4F PLA2G4F PLA2G4D PLA2G4D JMJD7 JMJD7 PRKCH PRKCH SYT16 SYT16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DAB2IPDAB2 interacting protein. (1196 aa)
PKN3Protein kinase N3. (861 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1190 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
SNRNP200U5 small nuclear ribonucleoprotein 200 kDa helicase isoform X1. (2136 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1618 aa)
LOC100625564Uncharacterized protein. (480 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)
RASAL1RAS protein activator like 1. (784 aa)
PTENUncharacterized protein. (576 aa)
SYT2Synaptotagmin 2. (417 aa)
CPNE4Copine-4 isoform 1. (575 aa)
MTMR14Myotubularin related protein 14. (728 aa)
SYTL4Synaptotagmin like 4. (721 aa)
CAPN6Calpain 6; Belongs to the peptidase C2 family. (624 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2056 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
RASAL3RAS protein activator like 3. (1012 aa)
TNS2Tensin 2. (1350 aa)
SYT9Synaptotagmin-9. (491 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
CAPN5Calpain 5; Belongs to the peptidase C2 family. (692 aa)
SYTL2Synaptotagmin like 2. (906 aa)
C2CD2LC2CD2 like. (707 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
SYT14Synaptotagmin 14. (801 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2201 aa)
TNS3Tensin 3. (1563 aa)
DOCK2Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
UNC13DUnc-13 homolog D. (1090 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
PLCD1Phosphoinositide phospholipase C. (724 aa)
C2CD2C2 calcium dependent domain containing 2. (709 aa)
RASA4BUncharacterized protein. (882 aa)
CPNE8Copine-8. (577 aa)
SYT8Synaptotagmin 8. (381 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (797 aa)
CC2D2BC2 domain-containing protein. (1442 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1348 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (995 aa)
AIDAAxin interactor, dorsalization associated. (349 aa)
ESYT1Extended synaptotagmin 1. (1109 aa)
SMURF1E3 ubiquitin-protein ligase. (859 aa)
DYSFDysferlin. (2119 aa)
UNC13BUncharacterized protein. (4266 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1265 aa)
RAB11FIP5Uncharacterized protein. (1391 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
TNS1Tensin 1. (1861 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1684 aa)
BAIAP3BAI1 associated protein 3. (1345 aa)
RPH3ARabphilin-3A isoform 1. (701 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (981 aa)
ITSN2Intersectin 2. (1695 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
SYTL1Synaptotagmin like 1. (602 aa)
WWC1WW and C2 domain containing 1. (1114 aa)
WWP1E3 ubiquitin-protein ligase. (923 aa)
SYTL5Synaptotagmin-like protein 5 isoform X1. (754 aa)
ABRABR activator of RhoGEF and GTPase. (964 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
OTOFOtoferlin. (1997 aa)
PLA2G4APhospholipase A2. (758 aa)
MYOFMyoferlin. (2182 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1293 aa)
C2CD4CC2 calcium dependent domain containing 4C. (420 aa)
WWP2E3 ubiquitin-protein ligase. (895 aa)
CC2D1BCoiled-coil and C2 domain containing 1B. (863 aa)
SYT12Synaptotagmin-12 isoform X3. (421 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
GAKCyclin G associated kinase. (1233 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1511 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (269 aa)
C2CD4DC2 calcium dependent domain containing 4D. (353 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2312 aa)
PKN2Serine/threonine-protein kinase N2 isoform 1. (983 aa)
RPGRIP1LProtein fantom isoform X1. (1270 aa)
RASAL2RAS protein activator like 2. (1279 aa)
UVRAGUV radiation resistance associated. (748 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (973 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (1998 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SYT4Synaptotagmin 4. (425 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
SYT10Synaptotagmin-10. (523 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (639 aa)
SYT1Synaptotagmin 1. (379 aa)
CCDC33Coiled-coil domain containing 33. (740 aa)
CPNE6Copine 6. (556 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TOLLIPCUE domain-containing protein. (272 aa)
SYT6Synaptotagmin 6. (532 aa)
PLCH2Phosphoinositide phospholipase C. (1329 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2203 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1602 aa)
BCRBCR activator of RhoGEF and GTPase. (1274 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2 isoform X3. (912 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2071 aa)
UNC13AUncharacterized protein. (1581 aa)
CPNE5Copine 5. (610 aa)
FER1L6Fer-1 like family member 6. (1858 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates [...] (1102 aa)
A0A287ASP1_PIGUncharacterized protein. (150 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
SYT13Synaptotagmin-13 isoform 1. (426 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2290 aa)
RAB11FIP1Uncharacterized protein. (642 aa)
SYT7Synaptotagmin-7 isoform X2. (686 aa)
PKN1Protein kinase N1. (956 aa)
WWC2WW and C2 domain containing 2. (873 aa)
PRF1Perforin 1. (555 aa)
SYT11Synaptotagmin 11. (438 aa)
SYT17Synaptotagmin 17. (505 aa)
CPNE3Copine 3. (571 aa)
CEP120Centrosomal protein 120. (992 aa)
DOCK6Dedicator of cytokinesis 6; Belongs to the DOCK family. (2123 aa)
PLCL2Phosphoinositide phospholipase C. (1128 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLA2G4EPhospholipase A2. (872 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
ESYT2Extended synaptotagmin 2. (863 aa)
WWC3WWC family member 3. (1216 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (938 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
UNC13CUnc-13 homolog C. (2214 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
RAB11FIP2Rab11 family-interacting protein 2 isoform 1. (512 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa)
PLCH1Phosphoinositide phospholipase C. (1690 aa)
RPGRIP1RPGR interacting protein 1. (939 aa)
TC2NTandem C2 domains nuclear protein isoform 1. (490 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SYT3Synaptotagmin-3 isoform X1. (591 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
SYTL3Synaptotagmin like 3. (610 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
PLA2G4FPhospholipase A2. (852 aa)
PLA2G4DPhospholipase A2. (812 aa)
JMJD7Phospholipase A2. (780 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
SYT16Synaptotagmin 16. (645 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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