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MAGT1 MAGT1 GPX8 GPX8 UBXN7 UBXN7 DIO1 DIO1 SELENOF SELENOF PRXL2B PRXL2B SELENOM SELENOM SH3BGR SH3BGR NXN NXN LOC100510917 LOC100510917 TMX4 TMX4 LOC100153094 LOC100153094 TXNDC15 TXNDC15 SPATA20 SPATA20 MIEN1 MIEN1 PDC PDC PDIA4 PDIA4 NME8 NME8 C2H5orf63 C2H5orf63 F1RMF5_PIG F1RMF5_PIG EEF1G EEF1G PRDX5 PRDX5 LOC100739163 LOC100739163 F1SL35_PIG F1SL35_PIG PDIA5 PDIA5 PRDX3 PRDX3 NHLRC2 NHLRC2 GSTO2 GSTO2 GSTO1 GSTO1 F1S5N8_PIG F1S5N8_PIG GSTT4 GSTT4 ERP29 ERP29 HPGDS HPGDS PDCL2 PDCL2 GRXCR1 GRXCR1 PDIA6 PDIA6 TXNDC9 TXNDC9 TXNDC11 TXNDC11 GSTM3 GSTM3 CASQ2 CASQ2 CASQ1 CASQ1 PTGES2 PTGES2 PDIA3 PDIA3 TXNL1 TXNL1 F1SV61_PIG F1SV61_PIG DNAJC16 DNAJC16 SELENOV SELENOV GSTA4 GSTA4 GSTA1 GSTA1 GLRX5 GLRX5 GPX2 GPX2 GPX5 GPX5 GPX6 GPX6 ERP27 ERP27 GSTZ1 GSTZ1 A0A5G2R4D9_PIG A0A5G2R4D9_PIG FAF1 FAF1 GLRX3 GLRX3 SH3BGRL2 SH3BGRL2 TMX3 TMX3 TMX1 TMX1 QSOX1 QSOX1 NDUFA2 NDUFA2 P4HB P4HB ERP44 ERP44 CLIC2 CLIC2 TXNL4B TXNL4B GLRX2 GLRX2 MRPS25 MRPS25 TXNDC12 TXNDC12 MRPL43 MRPL43 TXNDC8 TXNDC8 TMX2 TMX2 UBXN4 UBXN4 GSTK1 GSTK1 TXNRD3 TXNRD3 PRDX4 PRDX4 SCO2 SCO2 CLIC5 CLIC5 TXN TXN GLRX GLRX PRXL2C PRXL2C NDUFV2 NDUFV2 TUSC3 TUSC3 A0A287BCA6_PIG A0A287BCA6_PIG PRDX6 PRDX6 DIO3 DIO3 PDILT PDILT CLIC1 CLIC1 A0A287AWM8_PIG A0A287AWM8_PIG NXNL1 NXNL1 A0A287ASH7_PIG A0A287ASH7_PIG DIO2 DIO2 GPX4 GPX4 TXNDC5 TXNDC5 QSOX2 QSOX2 A0A287ANJ1_PIG A0A287ANJ1_PIG CLIC6 CLIC6 SELENOW SELENOW PDCL3 PDCL3 GPX3 GPX3 GPX1 GPX1 SELENOH SELENOH A0A287AEJ4_PIG A0A287AEJ4_PIG CLIC4 CLIC4 SCO1 SCO1 A0A287AB76_PIG A0A287AB76_PIG NME9 NME9 CLIC3 CLIC3 PRDX2 PRDX2 TXN2 TXN2 GPX7 GPX7 TXNL4A TXNL4A DNAJC10 DNAJC10 TXNDC17 TXNDC17 SH3BGRL3 SH3BGRL3 PDCL PDCL GDAP1L1 GDAP1L1 PRDX1 PRDX1 FAF2 FAF2 NXNL2 NXNL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAGT1Magnesium transporter protein 1. (372 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa)
UBXN7UBX domain-containing protein. (519 aa)
DIO1Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). (249 aa)
SELENOFSelenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity). (162 aa)
PRXL2BProstamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). (202 aa)
SELENOMSep15_SelM domain-containing protein. (142 aa)
SH3BGRUncharacterized protein. (205 aa)
NXNNucleoredoxin. (439 aa)
LOC100510917Uncharacterized protein. (222 aa)
TMX4Uncharacterized protein. (360 aa)
LOC100153094Uncharacterized protein; Belongs to the GST superfamily. (353 aa)
TXNDC15Thioredoxin domain-containing protein. (352 aa)
SPATA20Spermatogenesis-associated protein 20; May play a role in fertility regulation. (789 aa)
MIEN1Migration and invasion enhancer 1. (164 aa)
PDCPhosducin. (245 aa)
PDIA4Protein disulfide-isomerase. (646 aa)
NME8NME/NM23 family member 8. (588 aa)
C2H5orf63Glutaredoxin-like protein; Belongs to the glutaredoxin family. (129 aa)
F1RMF5_PIGGlutaredoxin domain-containing protein. (106 aa)
EEF1GElongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (436 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (170 aa)
LOC100739163Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (309 aa)
F1SL35_PIGUncharacterized protein; Belongs to the GST superfamily. (256 aa)
PDIA5Protein disulfide isomerase family A member 5. (566 aa)
PRDX3Thioredoxin domain-containing protein. (261 aa)
NHLRC2NHL repeat-containing protein 2. (725 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
GSTO1Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. (241 aa)
F1S5N8_PIGUncharacterized protein; Belongs to the GST superfamily. (217 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
PDCL2Phosducin like 2. (241 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
PDIA6Uncharacterized protein; Belongs to the protein disulfide isomerase family. (590 aa)
TXNDC9Thioredoxin domain-containing protein 9. (226 aa)
TXNDC11Thioredoxin domain-containing protein 11 isoform 2. (951 aa)
GSTM3Glutathione S-transferase. (225 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (405 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (402 aa)
PTGES2Prostaglandin E synthase 2. (372 aa)
PDIA3Protein disulfide-isomerase. (504 aa)
TXNL1Thioredoxin like 1. (394 aa)
F1SV61_PIGUncharacterized protein. (337 aa)
DNAJC16DnaJ heat shock protein family (Hsp40) member C16. (782 aa)
SELENOVUncharacterized protein. (342 aa)
GSTA4Glutathione S-transferase alpha 4. (223 aa)
GSTA1Glutathione S-transferase alpha M14, N-terminally processed; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (298 aa)
GLRX5Glutaredoxin 5. (154 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
GPX5Epididymal secretory glutathione peroxidase; May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. (219 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
ERP27Endoplasmic reticulum protein 27. (272 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (247 aa)
A0A5G2R4D9_PIGGlutathione S-transferase. (348 aa)
FAF1Fas associated factor 1. (657 aa)
GLRX3Glutaredoxin 3. (461 aa)
SH3BGRL2SH3 domain binding glutamate rich protein like 2. (121 aa)
TMX3Thioredoxin related transmembrane protein 3. (454 aa)
TMX1Thioredoxin-related transmembrane protein 1. (278 aa)
QSOX1Sulfhydryl oxidase. (742 aa)
NDUFA2NADH:ubiquinone oxidoreductase subunit A2. (105 aa)
P4HBProtein disulfide-isomerase. (623 aa)
ERP44Thioredoxin domain-containing protein. (460 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (259 aa)
TXNL4BThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
GLRX2Glutaredoxin domain-containing protein. (293 aa)
MRPS25Interferon alpha-inducible protein 6. (173 aa)
TXNDC12Thioredoxin domain-containing protein 12. (171 aa)
MRPL43Mitochondrial ribosomal protein L43. (217 aa)
TXNDC8Thioredoxin domain-containing protein. (155 aa)
TMX2Thioredoxin related transmembrane protein 2. (322 aa)
UBXN4UBX domain-containing protein 4. (508 aa)
GSTK1DSBA domain-containing protein. (243 aa)
TXNRD3Thioredoxin reductase 3; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (622 aa)
PRDX4Peroxiredoxin 4. (276 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (264 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (413 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (169 aa)
GLRXGlutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. (106 aa)
PRXL2CThioredoxin-like protein AAED1. (228 aa)
NDUFV2NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial. (249 aa)
TUSC3Tumor suppressor candidate 3. (348 aa)
A0A287BCA6_PIGThioredoxin domain-containing protein. (99 aa)
PRDX6Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa)
DIO3Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. (305 aa)
PDILTProtein disulfide isomerase like, testis expressed. (579 aa)
CLIC1Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (248 aa)
A0A287AWM8_PIGGlutaredoxin domain-containing protein. (106 aa)
NXNL1Nucleoredoxin like 1. (214 aa)
A0A287ASH7_PIGDSBA domain-containing protein. (150 aa)
DIO2Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa)
GPX4Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of s [...] (197 aa)
TXNDC5Thioredoxin domain containing 5. (431 aa)
QSOX2Sulfhydryl oxidase. (701 aa)
A0A287ANJ1_PIGGlutaredoxin domain-containing protein. (106 aa)
CLIC6Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (599 aa)
SELENOWSelenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity). (90 aa)
PDCL3Phosducin-like protein 3. (240 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa)
SELENOHUncharacterized protein. (122 aa)
A0A287AEJ4_PIGSH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (93 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (305 aa)
A0A287AB76_PIGGlutaredoxin domain-containing protein. (106 aa)
NME9Thioredoxin domain-containing protein 6 isoform g; Belongs to the NDK family. (350 aa)
CLIC3Chloride intracellular channel protein 3. (237 aa)
PRDX2Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (237 aa)
TXN2Thioredoxin 2. (255 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (317 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
DNAJC10DnaJ heat shock protein family (Hsp40) member C10. (803 aa)
TXNDC17Thioredoxin domain containing 17. (123 aa)
SH3BGRL3SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (93 aa)
PDCLPhosducin-like protein. (301 aa)
GDAP1L1Ganglioside-induced differentiation-associated protein 1-like 1 isoform 2. (367 aa)
PRDX1Peroxiredoxin-1. (224 aa)
FAF2Fas associated factor family member 2. (445 aa)
NXNL2Nucleoredoxin like 2. (156 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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