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COL22A1 COL22A1 ITGAM ITGAM CLCA2 CLCA2 PSMD4 PSMD4 HMCN2 HMCN2 COL12A1 COL12A1 MDN1 MDN1 VWA1 VWA1 MED25 MED25 CPNE6 CPNE6 SEC23A SEC23A C2 C2 VWF VWF VWA3A VWA3A VWA5B2 VWA5B2 COL21A1 COL21A1 ITGB3 ITGB3 COL6A6 COL6A6 XRCC6 XRCC6 ITGB4 ITGB4 ITGA1 ITGA1 ANTXR1 ANTXR1 COL14A1 COL14A1 ANTXRL ANTXRL ITIH3 ITIH3 INTS14 INTS14 CPNE3 CPNE3 COL6A5 COL6A5 COL28A1 COL28A1 VWA5A VWA5A HMCN1 HMCN1 ITGA11 ITGA11 RO60 RO60 ITIH1 ITIH1 ANTXR2 ANTXR2 ITGB5 ITGB5 MATN2 MATN2 SEC24A SEC24A SEC23B SEC23B ITGB8 ITGB8 CPNE5 CPNE5 ITGB2 ITGB2 ITGB6 ITGB6 ITGB7 ITGB7 GTF2H3 GTF2H3 COL20A1 COL20A1 SVEP1 SVEP1 CACNA2D3 CACNA2D3 CLCA1 CLCA1 ITIH4 ITIH4 VWA7 VWA7 BABAM1 BABAM1 CACNA2D2 CACNA2D2 ITGAE ITGAE ITGB1 ITGB1 INTS6L INTS6L COL6A2 COL6A2 VIT VIT COCH COCH CACNA2D4 CACNA2D4 CPNE8 CPNE8 MATN1 MATN1 ITGA2 ITGA2 COL7A1 COL7A1 CPNE4 CPNE4 ITIH5 ITIH5 ITIH2 ITIH2 VWA2 VWA2 SEC24C SEC24C SEC24B SEC24B SEC24D SEC24D MATN3 MATN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL22A1Collagen type XXII alpha 1 chain. (1602 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa)
CLCA2Chloride channel accessory 2. (943 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
HMCN2Hemicentin 2. (5047 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5596 aa)
VWA1Von Willebrand factor A domain containing 1. (480 aa)
MED25Mediator complex subunit 25. (794 aa)
CPNE6Copine 6. (556 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (853 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)
VWA3AVon Willebrand factor A domain containing 3A. (1188 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1248 aa)
COL21A1Collagen type XXI alpha 1 chain. (957 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
XRCC6X-ray repair cross complementing 6. (606 aa)
ITGB4Integrin beta. (1814 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
ANTXR1ANTXR cell adhesion molecule 1. (564 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
ANTXRLVWFA domain-containing protein. (208 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (907 aa)
INTS14Von Willebrand factor A domain-containing protein 9 isoform X1. (518 aa)
CPNE3Copine 3. (571 aa)
COL6A5Collagen type VI alpha 5 chain. (2337 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1236 aa)
VWA5AVon Willebrand factor A domain containing 5A. (844 aa)
HMCN1Hemicentin-1. (5636 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1282 aa)
RO60Ro60, Y RNA binding protein. (538 aa)
ITIH1Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (927 aa)
ANTXR2Anthrax toxin receptor; Belongs to the ATR family. (488 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
MATN2Matrilin 2. (956 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1133 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (722 aa)
CPNE5Copine 5. (610 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (903 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (854 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (882 aa)
GTF2H3General transcription factor IIH subunit 3 isoform a. (321 aa)
COL20A1Uncharacterized protein. (1338 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3532 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1092 aa)
CLCA1Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells. Belongs to the CLCR family. (915 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. (976 aa)
VWA7Uncharacterized protein. (891 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1068 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1168 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
INTS6LIntegrator complex subunit 6 like. (898 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
VITVitrin. (656 aa)
COCHCochlin isoform X2. (551 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1114 aa)
CPNE8Copine-8. (577 aa)
MATN1Matrilin 1. (496 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
COL7A1Uncharacterized protein. (2938 aa)
CPNE4Copine-4 isoform 1. (575 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain 5. (944 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. (923 aa)
VWA2Von Willebrand factor A domain containing 2. (735 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1118 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1258 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1033 aa)
MATN3Matrilin 3. (487 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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