(22 nodes) Frizzled cysteine-rich domain superfamily network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MUSK	Muscle associated receptor tyrosine kinase. (869 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	FZD6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
	SFRP2	Uncharacterized protein. (294 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	SFRP5	Uncharacterized protein. (315 aa)
	MFRP	Membrane frizzled-related protein. (568 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	COL18A1	Collagen type XVIII alpha 1 chain. (1755 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SFRP4	Secreted frizzled-related protein 4. (346 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
	CORIN	Corin, serine peptidase. (1113 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
	FRZB	Secreted frizzled-related protein 3. (325 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
	CPZ	Carboxypeptidase Z. (666 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CORIN	CPZ	ENSSSCP00000042872	ENSSSCP00000067026	Corin, serine peptidase.	Carboxypeptidase Z.	0.405
CPZ	CORIN	ENSSSCP00000067026	ENSSSCP00000042872	Carboxypeptidase Z.	Corin, serine peptidase.	0.405
CPZ	ROR2	ENSSSCP00000067026	ENSSSCP00000010242	Carboxypeptidase Z.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.497
FRZB	SFRP2	ENSSSCP00000043537	ENSSSCP00000009608	Secreted frizzled-related protein 3.	Uncharacterized protein.	0.476
FZD1	FZD2	ENSSSCP00000043267	ENSSSCP00000042537	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
FZD1	ROR1	ENSSSCP00000043267	ENSSSCP00000004123	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.920
FZD1	ROR2	ENSSSCP00000043267	ENSSSCP00000010242	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.923
FZD1	SFRP1	ENSSSCP00000043267	ENSSSCP00000029500	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1.	0.723
FZD1	SFRP2	ENSSSCP00000043267	ENSSSCP00000009608	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.704
FZD1	SFRP4	ENSSSCP00000043267	ENSSSCP00000038384	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 4.	0.670
FZD1	SFRP5	ENSSSCP00000043267	ENSSSCP00000011218	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.702
FZD10	ROR1	ENSSSCP00000010412	ENSSSCP00000004123	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.922
FZD10	ROR2	ENSSSCP00000010412	ENSSSCP00000010242	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.919
FZD10	SFRP1	ENSSSCP00000010412	ENSSSCP00000029500	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 1.	0.673
FZD10	SFRP2	ENSSSCP00000010412	ENSSSCP00000009608	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.650
FZD10	SFRP4	ENSSSCP00000010412	ENSSSCP00000038384	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 4.	0.662
FZD10	SFRP5	ENSSSCP00000010412	ENSSSCP00000011218	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.673
FZD2	FZD1	ENSSSCP00000042537	ENSSSCP00000043267	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
FZD2	FZD3	ENSSSCP00000042537	ENSSSCP00000034313	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.545
FZD2	FZD5	ENSSSCP00000042537	ENSSSCP00000017100	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.550