(11 nodes) Bcl-2-like superfamily network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2L14	BCL2 like 14. (329 aa)
	BCL2L12	BCL2 like 12. (255 aa)
	BCL2L10	Uncharacterized protein. (184 aa)
	BAK1	Uncharacterized protein. (266 aa)
	BCL2L1	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
	BCL2A1	Bcl-2-related protein A1 isoform 1. (175 aa)
	BCL2L15	Bcl-2-like protein 15. (163 aa)
	PABPN1	BCL2L2-PABPN1 protein. (333 aa)
	BID	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1. (351 aa)
	BCL2L13	BCL2 like 13. (470 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2A1	ENSSSCP00000032742	ENSSSCP00000034483	Uncharacterized protein.	Bcl-2-related protein A1 isoform 1.	0.917
BAK1	BCL2L1	ENSSSCP00000032742	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAK1	BCL2L10	ENSSSCP00000032742	ENSSSCP00000004982	Uncharacterized protein.	Uncharacterized protein.	0.633
BAK1	BID	ENSSSCP00000032742	ENSSSCP00000048980	Uncharacterized protein.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.993
BAK1	MCL1	ENSSSCP00000032742	ENSSSCP00000056528	Uncharacterized protein.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.874
BCL2A1	BAK1	ENSSSCP00000034483	ENSSSCP00000032742	Bcl-2-related protein A1 isoform 1.	Uncharacterized protein.	0.917
BCL2A1	BCL2L10	ENSSSCP00000034483	ENSSSCP00000004982	Bcl-2-related protein A1 isoform 1.	Uncharacterized protein.	0.465
BCL2A1	BID	ENSSSCP00000034483	ENSSSCP00000048980	Bcl-2-related protein A1 isoform 1.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.864
BCL2A1	MCL1	ENSSSCP00000034483	ENSSSCP00000056528	Bcl-2-related protein A1 isoform 1.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.434
BCL2L1	BAK1	ENSSSCP00000033436	ENSSSCP00000032742	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	Uncharacterized protein.	0.998
BCL2L1	BCL2L10	ENSSSCP00000033436	ENSSSCP00000004982	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	Uncharacterized protein.	0.474
BCL2L1	BID	ENSSSCP00000033436	ENSSSCP00000048980	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.994
BCL2L1	MCL1	ENSSSCP00000033436	ENSSSCP00000056528	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.790
BCL2L10	BAK1	ENSSSCP00000004982	ENSSSCP00000032742	Uncharacterized protein.	Uncharacterized protein.	0.633
BCL2L10	BCL2A1	ENSSSCP00000004982	ENSSSCP00000034483	Uncharacterized protein.	Bcl-2-related protein A1 isoform 1.	0.465
BCL2L10	BCL2L1	ENSSSCP00000004982	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.474
BCL2L10	BCL2L14	ENSSSCP00000004982	ENSSSCP00000000654	Uncharacterized protein.	BCL2 like 14.	0.503
BCL2L10	BID	ENSSSCP00000004982	ENSSSCP00000048980	Uncharacterized protein.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.540
BCL2L12	MCL1	ENSSSCP00000003445	ENSSSCP00000056528	BCL2 like 12.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.433
BCL2L13	BCL2L15	ENSSSCP00000067051	ENSSSCP00000042050	BCL2 like 13.	Bcl-2-like protein 15.	0.424