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CAPN5 CAPN5 USP35 USP35 CTSC CTSC USP37 USP37 USP40 USP40 BLMH BLMH USP43 USP43 SENP8 SENP8 USP38 USP38 OTUD5 OTUD5 UCHL1 UCHL1 USP14 USP14 CAPN7 CAPN7 USP20 USP20 CAPN14 CAPN14 SENP7 SENP7 TINAG TINAG USP24 USP24 LOC102162178 LOC102162178 USP53 USP53 CTSB CTSB USPL1 USPL1 LOC100625207 LOC100625207 CEP76 CEP76 ATG4A ATG4A TGM1 TGM1 USP22 USP22 LOC100626328 LOC100626328 USP16 USP16 A0A286ZRB2_PIG A0A286ZRB2_PIG OTUD4 OTUD4 ATG4D ATG4D OTUD1 OTUD1 USP31 USP31 CTSW CTSW USP19 USP19 USP1 USP1 XPC XPC PAN2 PAN2 CYLD CYLD USP9X USP9X USP34 USP34 USP11 USP11 YOD1 YOD1 USP44 USP44 CTSO CTSO USP36 USP36 USP27X USP27X SENP5 SENP5 SENP2 SENP2 USP13 USP13 KY KY NGLY1 NGLY1 CTSV CTSV CTSL CTSL UCHL5 UCHL5 USP12 USP12 CAPN15 CAPN15 USP7 USP7 CTSZ CTSZ A0A480RQR3_PIG A0A480RQR3_PIG CTSS CTSS OTUD6B OTUD6B EPB42 EPB42 TGM5 TGM5 TGM7 TGM7 USP50 USP50 USP45 USP45 ADGB ADGB TINAGL1 TINAGL1 USP48 USP48 CAPN12 CAPN12 DRC7 DRC7 USP10 USP10 OTUB2 OTUB2 CTSH CTSH USP49 USP49 USP15 USP15 USP30 USP30 USP54 USP54 CAPN13 CAPN13 A0A287BGM8_PIG A0A287BGM8_PIG SENP1 SENP1 ATG4C ATG4C TGM6 TGM6 CAPN6 CAPN6 USP26 USP26 OTUB1 OTUB1 CTSF CTSF CAPN1 CAPN1 USP51 USP51 OTUD6A OTUD6A USP32 USP32 USP33 USP33 UCHL3 UCHL3 ATG4B ATG4B ALG13 ALG13 USP47 USP47 TGM2 TGM2 USP5 USP5 F13A1 F13A1 USP39 USP39 CAPN3 CAPN3 USP3 USP3 SENP3 SENP3 USP4 USP4 USP28 USP28 USP46 USP46 SENP6 SENP6 USP42 USP42 A0A287BBW6_PIG A0A287BBW6_PIG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAPN5Calpain 5; Belongs to the peptidase C2 family. (692 aa)
USP35Ubiquitin specific peptidase 35; Belongs to the peptidase C19 family. (1005 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
USP37Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] (980 aa)
USP40Ubiquitin carboxyl-terminal hydrolase 40 isoform X1; Belongs to the peptidase C19 family. (1222 aa)
BLMHBleomycin hydrolase; Belongs to the peptidase C1 family. (454 aa)
USP43Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1104 aa)
SENP8SUMO peptidase family member, NEDD8 specific. (212 aa)
USP38Ubiquitin carboxyl-terminal hydrolase 38 isoform 1; Belongs to the peptidase C19 family. (1041 aa)
OTUD5OTU deubiquitinase 5. (571 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity); Belongs to the peptidase C12 family. (223 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (505 aa)
CAPN7Calpain-7; Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family. (769 aa)
USP20Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (912 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (683 aa)
SENP7Sentrin-specific protease 7 isoform X1. (1051 aa)
TINAGTubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa)
USP24Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2619 aa)
LOC102162178USP domain-containing protein; Belongs to the peptidase C19 family. (690 aa)
USP53Ubiquitin specific peptidase 53. (1077 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
USPL1SUMO-specific isopeptidase USPL1 isoform X1. (1095 aa)
LOC100625207USP domain-containing protein; Belongs to the peptidase C19 family. (2554 aa)
CEP76Centrosomal protein 76. (659 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (489 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (826 aa)
USP22Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (522 aa)
LOC100626328Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (514 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (823 aa)
A0A286ZRB2_PIGUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (497 aa)
OTUD4OTU deubiquitinase 4. (1110 aa)
ATG4DCysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. (514 aa)
OTUD1OTU deubiquitinase 1. (478 aa)
USP31Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1338 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (368 aa)
USP19Ubiquitin specific peptidase 19. (1364 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (784 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (1018 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3522 aa)
USP11Ubiquitin specific peptidase 11; Belongs to the peptidase C19 family. (918 aa)
YOD1YOD1 deubiquitinase. (306 aa)
USP44Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (709 aa)
CTSOCathepsin O preproprotein; Belongs to the peptidase C1 family. (311 aa)
USP36Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (548 aa)
USP27XUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)
SENP5SUMO specific peptidase 5. (752 aa)
SENP2SUMO specific peptidase 2. (557 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
KYKyphoscoliosis peptidase. (662 aa)
NGLY1N-glycanase 1. (688 aa)
CTSVCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
CTSLCathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa)
USP12Ubiquitin specific peptidase 12; Belongs to the peptidase C19 family. (370 aa)
CAPN15Calpain 15; Belongs to the peptidase C2 family. (1008 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (304 aa)
A0A480RQR3_PIGArylamine N-acetyltransferase 1 isoform b; Belongs to the arylamine N-acetyltransferase family. (334 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
OTUD6BOTU domain containing 6B. (323 aa)
EPB42Erythrocyte membrane protein band 4.2. (688 aa)
TGM5Transglutaminase 5. (731 aa)
TGM7Transglutaminase 7. (710 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (373 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (817 aa)
ADGBRas-related protein Rab-32; Belongs to the peptidase C2 family. (1631 aa)
TINAGL1Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family. (500 aa)
USP48Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1063 aa)
CAPN12Calpain 12; Belongs to the peptidase C2 family. (718 aa)
DRC7Dynein regulatory complex subunit 7 isoform a. (875 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (805 aa)
OTUB2OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa)
CTSHCathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (335 aa)
USP49Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (682 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (924 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (516 aa)
USP54Ubiquitin specific peptidase 54. (1656 aa)
CAPN13Calpain 13; Belongs to the peptidase C2 family. (668 aa)
A0A287BGM8_PIGUbiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
SENP1SUMO specific peptidase 1. (677 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
TGM6Transglutaminase 6. (706 aa)
CAPN6Calpain 6; Belongs to the peptidase C2 family. (624 aa)
USP26Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (904 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (474 aa)
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (775 aa)
USP51Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (710 aa)
OTUD6AOTU deubiquitinase 6A. (289 aa)
USP32Uncharacterized protein; Belongs to the peptidase C19 family. (1632 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (911 aa)
UCHL3Ubiquitin carboxyl-terminal hydrolase isozyme L3; Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 [...] (294 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (402 aa)
ALG13Uncharacterized protein. (522 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1356 aa)
TGM2Transglutaminase 2. (696 aa)
USP5Ubiquitinyl hydrolase 1. (864 aa)
F13A1Coagulation factor XIII A chain. (774 aa)
USP39U4/U6.U5 tri-snRNP-associated protein 2 isoform 1. (565 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (830 aa)
USP3Ubiquitinyl hydrolase 1. (540 aa)
SENP3Sentrin-specific protease 3. (574 aa)
USP4Ubiquitin specific peptidase 4; Belongs to the peptidase C19 family. (979 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1130 aa)
USP46Ubiquitin carboxyl-terminal hydrolase 46 isoform 1; Belongs to the peptidase C19 family. (366 aa)
SENP6Sentrin-specific protease 6 isoform 1. (1145 aa)
USP42Ubiquitin specific peptidase 42; Belongs to the peptidase C19 family. (1344 aa)
A0A287BBW6_PIGUSP domain-containing protein. (314 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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