STRINGSTRING
BOC BOC MUSK MUSK VSIG10L2 VSIG10L2 CADM1 CADM1 TREM1 TREM1 NTRK3 NTRK3 LRIG2 LRIG2 NECTIN4 NECTIN4 CADM4 CADM4 IL6R IL6R MAG MAG ICOSLG ICOSLG KIT KIT MCAM MCAM CD47 CD47 KIRREL1 KIRREL1 ADGRA2 ADGRA2 CSF1R CSF1R FLT1 FLT1 KIRREL2 KIRREL2 NTM NTM AMIGO1 AMIGO1 NECTIN2 NECTIN2 A0A287BRI2_PIG A0A287BRI2_PIG LAC_PIG LAC_PIG MFAP3 MFAP3 FCGR1A FCGR1A BCAM BCAM LOC100517285 LOC100517285 TMEM25 TMEM25 ACAN ACAN IL1RAPL2 IL1RAPL2 THY1 THY1 FCGR3A FCGR3A NECTIN3 NECTIN3 B2M B2M LRFN1 LRFN1 PDGFRA PDGFRA ADGRA3 ADGRA3 LRFN4 LRFN4 IL12B IL12B A0A287ANX9_PIG A0A287ANX9_PIG PECAM1 PECAM1 LRRN1 LRRN1 CD22 CD22 KIR2DL1 KIR2DL1 LRIG3 LRIG3 CD3G CD3G FGFR3 FGFR3 VSTM1 VSTM1 PIGR PIGR CD200 CD200 AXL AXL SEMA3B SEMA3B NTRK2 NTRK2 LOC100512905 LOC100512905 A0A287A5U8_PIG A0A287A5U8_PIG A0A287A4Y3_PIG A0A287A4Y3_PIG NRCAM NRCAM LOC110261043 LOC110261043 LOC100525227 LOC100525227 MERTK MERTK LOC100522225 LOC100522225 PTPRM PTPRM CRTAM CRTAM NPHS1 NPHS1 SIGLEC1 SIGLEC1 ISLR2 ISLR2 A1BG A1BG A0A286ZTC9_PIG A0A286ZTC9_PIG CXADR CXADR CADM3 CADM3 FCRL3 FCRL3 LRIT1 LRIT1 VSIG10 VSIG10 CTLA4 CTLA4 PIGE-108A11.3 PIGE-108A11.3 IGSF1 IGSF1 FGFR4 FGFR4 LOC100521529 LOC100521529 FGFR2 FGFR2 ALCAM ALCAM FGFR1 FGFR1 LOC102158679 LOC102158679 SEMA4D SEMA4D KDR KDR CD86 CD86 CD101 CD101 FLT3 FLT3 CD1.1 CD1.1 PXDN PXDN SIGIRR SIGIRR I3LD26_PIG I3LD26_PIG CD4 CD4 SEMA3E SEMA3E NECTIN1 NECTIN1 CD3E CD3E PDGFRB PDGFRB HAPLN1 HAPLN1 FLT4 FLT4 IL1RAPL1 IL1RAPL1 CADM2 CADM2 CD80 CD80 SEMA3G SEMA3G LOC100523213 LOC100523213 ROR2 ROR2 IL1R2 IL1R2 BCAN BCAN NTRK1 NTRK1 SLAMF6 SLAMF6 CD274 CD274 TEK TEK TYRO3 TYRO3 TIE1 TIE1 ROR1 ROR1 NCR1 NCR1 FCAR FCAR F1RNG5_PIG F1RNG5_PIG LOC100515551 LOC100515551 LOC100525346 LOC100525346 ISLR ISLR PTK7 PTK7 LRFN2 LRFN2 BTNL2 BTNL2 AGER AGER AMIGO2 AMIGO2 LAG3 LAG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BOCBOC cell adhesion associated, oncogene regulated. (1241 aa)
MUSKMuscle associated receptor tyrosine kinase. (869 aa)
VSIG10L2V-set and immunoglobulin domain containing 10 like 2. (766 aa)
CADM1Cell adhesion molecule 1. (473 aa)
TREM1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1065 aa)
NECTIN4Nectin cell adhesion molecule 4. (525 aa)
CADM4Cell adhesion molecule 4. (405 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
MAGMyelin associated glycoprotein. (625 aa)
ICOSLGIg-like domain-containing protein. (483 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
MCAMMelanoma cell adhesion molecule. (667 aa)
CD47Leukocyte surface antigen CD47; Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Plays an important role in memory formation and synaptic plasticity in the hippocampus. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeabili [...] (340 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (773 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1336 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
KIRREL2Kirre like nephrin family adhesion molecule 2. (711 aa)
NTMNeurotrimin. (344 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (561 aa)
NECTIN2Uncharacterized protein. (616 aa)
A0A287BRI2_PIGIg-like domain-containing protein. (591 aa)
LAC_PIGIg lambda chain C region. (380 aa)
MFAP3Microfibril-associated glycoprotein 3 isoform 1. (362 aa)
FCGR1AUncharacterized protein. (362 aa)
BCAMBasal cell adhesion molecule (Lutheran blood group). (770 aa)
LOC100517285Ig-like domain-containing protein. (313 aa)
TMEM25Transmembrane protein 25. (407 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
IL1RAPL2Interleukin 1 receptor accessory protein like 2. (686 aa)
THY1Thy-1 cell surface antigen. (165 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. (259 aa)
NECTIN3Nectin cell adhesion molecule 3. (549 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (157 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (766 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1317 aa)
LRFN4Leucine-rich repeat and fibronectin type-III domain-containing protein 4 isoform X1. (636 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa)
A0A287ANX9_PIGUncharacterized protein. (472 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
LRRN1Leucine-rich repeat neuronal protein 1. (716 aa)
CD22CD22 molecule. (890 aa)
KIR2DL1Ig-like domain-containing protein. (336 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1088 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
VSTM1V-set and transmembrane domain containing 1. (219 aa)
PIGRPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface (By similarity). (792 aa)
CD200OX-2 membrane glycoprotein isoform X2. (301 aa)
AXLUncharacterized protein. (871 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (747 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LOC100512905Uncharacterized protein. (393 aa)
A0A287A5U8_PIGUncharacterized protein. (362 aa)
A0A287A4Y3_PIGIg-like domain-containing protein. (226 aa)
NRCAMNeuronal cell adhesion molecule. (1219 aa)
LOC110261043Uncharacterized protein. (387 aa)
LOC100525227Ig-like domain-containing protein. (464 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
LOC100522225Uncharacterized protein. (514 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1507 aa)
CRTAMCytotoxic and regulatory T cell molecule. (400 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1239 aa)
SIGLEC1Sialoadhesin; Macrophage-restricted adhesion molecule that mediates sialic- acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (By similarity). Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process. B [...] (1730 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (806 aa)
A1BGAlpha-1B-glycoprotein. (693 aa)
A0A286ZTC9_PIGUncharacterized protein. (647 aa)
CXADRUncharacterized protein. (419 aa)
CADM3Cell adhesion molecule 3 isoform 1. (430 aa)
FCRL3Fc receptor-like protein 3 isoform 1. (729 aa)
LRIT1Leucine rich repeat, Ig-like and transmembrane domains 1. (652 aa)
VSIG10V-set and immunoglobulin domain containing 10. (536 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
PIGE-108A11.3Ig-like domain-containing protein. (513 aa)
IGSF1Immunoglobulin superfamily member 1. (1307 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
LOC100521529Ig-like domain-containing protein. (481 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
ALCAMActivated leukocyte cell adhesion molecule. (619 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
LOC102158679Uncharacterized protein. (325 aa)
SEMA4DSemaphorin-4D isoform X1; Belongs to the semaphorin family. (865 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
CD86T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
CD101CD101 molecule. (1018 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
CD1.1T-cell surface glycoprotein CD1a; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (339 aa)
PXDNPeroxidasin. (1529 aa)
SIGIRRUncharacterized protein. (410 aa)
I3LD26_PIGUncharacterized protein. (279 aa)
CD4CD4 molecule. (494 aa)
SEMA3ESemaphorin-3E isoform 1; Belongs to the semaphorin family. (775 aa)
NECTIN1Nectin-1; Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells; Belongs to the nectin family. (515 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (267 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (354 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
CADM2Cell adhesion molecule 2. (438 aa)
CD80CD80 molecule. (297 aa)
SEMA3GSemaphorin-3G; Belongs to the semaphorin family. (771 aa)
LOC100523213Ig-like domain-containing protein. (212 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
IL1R2Interleukin 1 receptor type 2. (413 aa)
BCANBrevican core protein isoform X1. (906 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
SLAMF6SLAM family member 6. (321 aa)
CD274CD274 molecule. (311 aa)
TEKTEK receptor tyrosine kinase. (1147 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
NCR1Natural cytotoxicity triggering receptor 1. (308 aa)
FCARFc fragment of IgA receptor. (264 aa)
F1RNG5_PIGIg-like domain-containing protein. (254 aa)
LOC100515551Uncharacterized protein. (551 aa)
LOC100525346Uncharacterized protein. (459 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (436 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
LRFN2Leucine-rich repeat and fibronectin type-III domain-containing protein 2. (791 aa)
BTNL2Butyrophilin like 2. (587 aa)
AGERAdvanced glycosylation end-product specific receptor. (487 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
LAG3Uncharacterized protein. (507 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]