(8 nodes) Metallo-peptidase family M12B Reprolysin-like network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
	ADAM9	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
	ADAM19	ADAM metallopeptidase domain 19. (951 aa)
	ADAM8	Disintegrin and metalloproteinase domain-containing protein 8. (835 aa)
	ADAMTS10	Uncharacterized protein. (1102 aa)
	ADAM20	ADAM metallopeptidase domain 20. (737 aa)
	ADAM12	ADAM metallopeptidase domain 12. (918 aa)
	ADAM10	Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion [...] (748 aa)