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IFN-ALPHA-4 IFN-ALPHA-4 ISG15 ISG15 DDX58 DDX58 TNFSF15 TNFSF15 CXCL9 CXCL9 TP53 TP53 USP18 USP18 IRF2 IRF2 SOCS3 SOCS3 RSAD2 RSAD2 TRADD TRADD RIPK1 RIPK1 IRF9 IRF9 IFNA1 IFNA1 IFNAR1 IFNAR1 CCL4 CCL4 MASTL MASTL STAT2 STAT2 IFIT5 IFIT5 NFKBIZ NFKBIZ NFKBIA NFKBIA IFNB1 IFNB1 TRAF2 TRAF2 OAS2 OAS2 OASL OASL IFIT1 IFIT1 PTX3 PTX3 RELA RELA IRF1 IRF1 DHX58 DHX58 TNFSF9 TNFSF9 IL6 IL6 SOCS1 SOCS1 CASP8 CASP8 PMAIP1 PMAIP1 CCL5 CCL5 CXCR3 CXCR3 MX1 MX1 IFIT2 IFIT2 ENG ENG DUSP1 DUSP1 TNFAIP3 TNFAIP3 G0S2 G0S2 STAT1 STAT1 ZC3HAV1 ZC3HAV1 GCNT4 GCNT4 SGK1 SGK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFN-ALPHA-4Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (189 aa)
ISG15Ubiquitin-like modifier. (167 aa)
DDX58Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
TNFSF15TNF_2 domain-containing protein. (250 aa)
CXCL9C-X-C motif chemokine. (126 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (376 aa)
IRF2Interferon regulatory factor 2. (425 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
IRF9IRF tryptophan pentad repeat domain-containing protein. (418 aa)
IFNA1Uncharacterized protein. (189 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
MASTLMicrotubule associated serine/threonine kinase like. (881 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (489 aa)
NFKBIZNFKB inhibitor zeta. (747 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
IFNB1Interferon-beta-1. (186 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
OAS22'-5'-oligoadenylate synthetase 2. (713 aa)
OASL2'-5'-oligoadenylate synthase-like protein isoform a. (348 aa)
IFIT1Interferon-stimulated protein 60. (509 aa)
PTX3Pentraxin-related protein PTX3. (382 aa)
RELATranscription factor p65 isoform 1. (573 aa)
IRF1Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa)
DHX58DExH-box helicase 58. (681 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (259 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa)
PMAIP1Uncharacterized protein. (121 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CXCR3C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (473 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (353 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
G0S2G0/G1 switch 2 protein. (103 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
ZC3HAV1Zinc finger CCCH-type antiviral protein 1 isoform 1. (894 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (632 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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