(23 nodes) (2012) Genetically engineered immune privileged Sertoli cells: A new road to cell based gene therapy. network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	IFNB1	Interferon-beta-1. (186 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	CD4	CD4 molecule. (494 aa)
	OTC	Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (354 aa)
	ADA	Adenosine deaminase. (409 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (277 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
	AKT1	Non-specific serine/threonine protein kinase. (785 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	CD34	CD34 molecule. (393 aa)
	EEF1A1	Eukaryotic translation elongation factor 1 alpha 1. (502 aa)
	CD55	Uncharacterized protein. (609 aa)
	EEF1A2	Eukaryotic translation elongation factor 1 alpha 2. (588 aa)
	LOC100620900	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (454 aa)
	GATA4	Transcription factor GATA-4 isoform 2. (442 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (412 aa)
	SERPING1	Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa)
	LMO2	LIM domain only 2. (223 aa)
	LOC100514912	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (461 aa)
	IDO1	Uncharacterized protein. (429 aa)
	VCAM1	Uncharacterized protein. (537 aa)
	PTGES	Microsomal prostaglandin E synthase-1. (153 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	GCG	ENSSSCP00000070139	ENSSSCP00000016844	Adenosine deaminase.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.656
ADA	IL2	ENSSSCP00000070139	ENSSSCP00000059176	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.563
ADA	LMO2	ENSSSCP00000070139	ENSSSCP00000014139	Adenosine deaminase.	LIM domain only 2.	0.443
AKT1	IL6	ENSSSCP00000050721	ENSSSCP00000023819	Non-specific serine/threonine protein kinase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.405
AKT1	INS	ENSSSCP00000050721	ENSSSCP00000044635	Non-specific serine/threonine protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.510
CD34	CD4	ENSSSCP00000038479	ENSSSCP00000019155	CD34 molecule.	CD4 molecule.	0.779
CD34	CD55	ENSSSCP00000038479	ENSSSCP00000033510	CD34 molecule.	Uncharacterized protein.	0.410
CD34	GATA4	ENSSSCP00000038479	ENSSSCP00000027951	CD34 molecule.	Transcription factor GATA-4 isoform 2.	0.635
CD34	IDO1	ENSSSCP00000038479	ENSSSCP00000007468	CD34 molecule.	Uncharacterized protein.	0.529
CD34	IDO2	ENSSSCP00000038479	ENSSSCP00000025192	CD34 molecule.	Indoleamine 2,3-dioxygenase 2.	0.433
CD34	IL2	ENSSSCP00000038479	ENSSSCP00000059176	CD34 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.603
CD34	IL6	ENSSSCP00000038479	ENSSSCP00000023819	CD34 molecule.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.757
CD34	INS	ENSSSCP00000038479	ENSSSCP00000044635	CD34 molecule.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.756
CD34	LMO2	ENSSSCP00000038479	ENSSSCP00000014139	CD34 molecule.	LIM domain only 2.	0.552
CD34	VCAM1	ENSSSCP00000038479	ENSSSCP00000007316	CD34 molecule.	Uncharacterized protein.	0.498
CD4	CD34	ENSSSCP00000019155	ENSSSCP00000038479	CD4 molecule.	CD34 molecule.	0.779
CD4	CD55	ENSSSCP00000019155	ENSSSCP00000033510	CD4 molecule.	Uncharacterized protein.	0.528
CD4	GCG	ENSSSCP00000019155	ENSSSCP00000016844	CD4 molecule.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.412
CD4	IDO1	ENSSSCP00000019155	ENSSSCP00000007468	CD4 molecule.	Uncharacterized protein.	0.737
CD4	IDO2	ENSSSCP00000019155	ENSSSCP00000025192	CD4 molecule.	Indoleamine 2,3-dioxygenase 2.	0.679