node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH9A1 | BBOX1 | ENSSSCP00000006743 | ENSSSCP00000014170 | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. | Gamma-butyrobetaine hydroxylase 1. | 0.964 |
ALDH9A1 | SLC22A2 | ENSSSCP00000006743 | ENSSSCP00000004366 | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | 0.475 |
BBOX1 | ALDH9A1 | ENSSSCP00000014170 | ENSSSCP00000006743 | Gamma-butyrobetaine hydroxylase 1. | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. | 0.964 |
BBOX1 | SLC22A2 | ENSSSCP00000014170 | ENSSSCP00000004366 | Gamma-butyrobetaine hydroxylase 1. | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | 0.607 |
CALM3 | CALML4 | ENSSSCP00000068530 | ENSSSCP00000071054 | Uncharacterized protein; Belongs to the calmodulin family. | Uncharacterized protein. | 0.964 |
CALM3 | CALML5 | ENSSSCP00000068530 | ENSSSCP00000011880 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin like 5. | 0.963 |
CALML4 | CALM3 | ENSSSCP00000071054 | ENSSSCP00000068530 | Uncharacterized protein. | Uncharacterized protein; Belongs to the calmodulin family. | 0.964 |
CALML4 | CALML5 | ENSSSCP00000071054 | ENSSSCP00000011880 | Uncharacterized protein. | Calmodulin like 5. | 0.966 |
CALML5 | CALM3 | ENSSSCP00000011880 | ENSSSCP00000068530 | Calmodulin like 5. | Uncharacterized protein; Belongs to the calmodulin family. | 0.963 |
CALML5 | CALML4 | ENSSSCP00000011880 | ENSSSCP00000071054 | Calmodulin like 5. | Uncharacterized protein. | 0.966 |
CPT1B | PPARA | ENSSSCP00000044392 | ENSSSCP00000000007 | Carnitine O-palmitoyltransferase 1, muscle isoform. | Uncharacterized protein. | 0.628 |
CPT1B | PPARGC1A | ENSSSCP00000044392 | ENSSSCP00000032437 | Carnitine O-palmitoyltransferase 1, muscle isoform. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.706 |
PPARA | CPT1B | ENSSSCP00000000007 | ENSSSCP00000044392 | Uncharacterized protein. | Carnitine O-palmitoyltransferase 1, muscle isoform. | 0.628 |
PPARA | PPARGC1A | ENSSSCP00000000007 | ENSSSCP00000032437 | Uncharacterized protein. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.999 |
PPARGC1A | CPT1B | ENSSSCP00000032437 | ENSSSCP00000044392 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | Carnitine O-palmitoyltransferase 1, muscle isoform. | 0.706 |
PPARGC1A | PPARA | ENSSSCP00000032437 | ENSSSCP00000000007 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | Uncharacterized protein. | 0.999 |
SLC22A2 | ALDH9A1 | ENSSSCP00000004366 | ENSSSCP00000006743 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. | 0.475 |
SLC22A2 | BBOX1 | ENSSSCP00000004366 | ENSSSCP00000014170 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | Gamma-butyrobetaine hydroxylase 1. | 0.607 |