STRINGSTRING
LDLR LDLR POU5F1 POU5F1 FOXA3 FOXA3 UGT2B31 UGT2B31 HGF HGF LOC100515394 LOC100515394 ELANE ELANE I3LP71_PIG I3LP71_PIG GATA4 GATA4 FMR1 FMR1 LOC100515741 LOC100515741 FOXA2 FOXA2 EOMES EOMES TARDBP TARDBP FOXA1 FOXA1 INS INS ALB ALB SMAD2 SMAD2 NANOG NANOG LOC100623504 LOC100623504 FAH FAH APOA2 APOA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
FOXA3Forkhead box A3. (350 aa)
UGT2B31UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
LOC100515394UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
I3LP71_PIGUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (391 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
FMR1Fragile X mental retardation protein 1. (632 aa)
LOC100515741UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (515 aa)
FOXA2Hepatocyte nuclear factor 3-beta isoform 1. (463 aa)
EOMESEomesodermin. (704 aa)
TARDBPTAR DNA binding protein. (414 aa)
FOXA1Forkhead box A1. (468 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
SMAD2Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] (472 aa)
NANOGHomeobox domain-containing protein. (304 aa)
LOC100623504UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (430 aa)
FAHFumarylacetoacetase. (480 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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