STRINGSTRING
NPC2 NPC2 LIMK1 LIMK1 CD2AP CD2AP PLG PLG S1PR5 S1PR5 PXN PXN FAS FAS FLT1 FLT1 ASAH2 ASAH2 CERK CERK SMPDL3B SMPDL3B GLA GLA LRP2 LRP2 RHOA RHOA SPTLC2 SPTLC2 SORT1 SORT1 NPHS1 NPHS1 CERS2 CERS2 GALC GALC SPHK2 SPHK2 SPHK1 SPHK1 PODXL PODXL MTOR MTOR NPHS2 NPHS2 CERS4 CERS4 SPTLC1 SPTLC1 SPTLC3 SPTLC3 CERS3 CERS3 NPC1 NPC1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NPC2NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmos [...] (154 aa)
LIMK1LIM domain kinase 1. (681 aa)
CD2APCD2 associated protein. (643 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
S1PR5Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins (By similarity). (463 aa)
PXNUncharacterized protein. (1072 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
ASAH2Neutral ceramidase. (786 aa)
CERKCeramide kinase. (536 aa)
SMPDL3BSphingomyelin phosphodiesterase acid like 3B. (406 aa)
GLAAlpha-galactosidase. (433 aa)
LRP2Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
SORT1Sortilin. (963 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1239 aa)
CERS2Ceramide synthase 2 isoform X1. (524 aa)
GALCGalactocerebrosidase isoform a. (685 aa)
SPHK2Sphingosine kinase 2. (653 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (516 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
NPHS2NPHS2 stomatin family member, podocin. (378 aa)
CERS4Ceramide synthase 4. (393 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (548 aa)
CERS3Ceramide synthase 3. (385 aa)
NPC1NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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