48 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)
	KERA	Keratocan. (351 aa)
	LOXL1	Lysyl oxidase like 1. (591 aa)
	FBN1	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	OTX2	Orthodenticle homeobox 2. (297 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa)
	PLAT	Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
	IL1B2	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1712 aa)
	CD44	CD44 molecule (Indian blood group). (767 aa)
	LOX	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
	MMP1	Stromelysin-1 preproprotein. (477 aa)
	COCH	Cochlin isoform X2. (551 aa)
	PXDN	Peroxidasin. (1529 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. (338 aa)
	ICAM1	Intercellular adhesion molecule 1. (537 aa)
	FGFR2	Fibroblast growth factor receptor. (820 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
	PAX6	Paired box 6. (498 aa)
	FOXC1	Forkhead box C1. (544 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	ADAMTS10	Uncharacterized protein. (1102 aa)
	CCN2	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif 17. (1273 aa)
	MYOC	Myocilin. (489 aa)
	COL8A2	Collagen type VIII alpha 2 chain. (707 aa)
	MFAP1	Microfibril associated protein 1. (439 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (819 aa)
	ANGPTL7	Angiopoietin-related protein 7. (344 aa)
	PECAM1	Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	CDH5	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa)
	MMP9	Matrix metalloproteinase-9. (708 aa)
	PITX2	Homeobox protein. (326 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (381 aa)
	COL4A1	Collagen IV NC1 domain-containing protein. (461 aa)
	TGM2	Transglutaminase 2. (696 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (759 aa)
	COL11A1	Collagen type XI alpha 1 chain. (1816 aa)
	SPARC	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1814 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS10	COL8A2	ENSSSCP00000036538	ENSSSCP00000043314	Uncharacterized protein.	Collagen type VIII alpha 2 chain.	0.545
ADAMTS10	FBN1	ENSSSCP00000036538	ENSSSCP00000005017	Uncharacterized protein.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.810
ADAMTS10	LOX	ENSSSCP00000036538	ENSSSCP00000015138	Uncharacterized protein.	Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family.	0.414
ADAMTS10	LOXL1	ENSSSCP00000036538	ENSSSCP00000002093	Uncharacterized protein.	Lysyl oxidase like 1.	0.423
ADAMTS10	LTBP2	ENSSSCP00000036538	ENSSSCP00000073277	Uncharacterized protein.	Latent transforming growth factor beta binding protein 2.	0.676
ADAMTS17	FBN1	ENSSSCP00000039975	ENSSSCP00000005017	ADAM metallopeptidase with thrombospondin type 1 motif 17.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.525
ADAMTS17	LTBP2	ENSSSCP00000039975	ENSSSCP00000073277	ADAM metallopeptidase with thrombospondin type 1 motif 17.	Latent transforming growth factor beta binding protein 2.	0.504
ADAMTS4	BGN	ENSSSCP00000006778	ENSSSCP00000029666	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Biglycan; May be involved in collagen fiber assembly.	0.533
ADAMTS4	COL2A1	ENSSSCP00000006778	ENSSSCP00000036099	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Collagen type II alpha 1 chain.	0.751
ADAMTS4	DCN	ENSSSCP00000006778	ENSSSCP00000000977	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Decorin; May affect the rate of fibrils formation.	0.532
ADAMTS4	IL1A	ENSSSCP00000006778	ENSSSCP00000008638	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.	0.449
ADAMTS4	IL1B	ENSSSCP00000006778	ENSSSCP00000044922	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.557
ADAMTS4	IL1B2	ENSSSCP00000006778	ENSSSCP00000008635	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.579
ADAMTS4	MMP1	ENSSSCP00000006778	ENSSSCP00000015910	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Stromelysin-1 preproprotein.	0.849
ADAMTS4	MMP9	ENSSSCP00000006778	ENSSSCP00000049256	ADAM metallopeptidase with thrombospondin type 1 motif 4.	Matrix metalloproteinase-9.	0.644
ANGPTL7	MYOC	ENSSSCP00000044703	ENSSSCP00000040842	Angiopoietin-related protein 7.	Myocilin.	0.649
BGN	ADAMTS4	ENSSSCP00000029666	ENSSSCP00000006778	Biglycan; May be involved in collagen fiber assembly.	ADAM metallopeptidase with thrombospondin type 1 motif 4.	0.533
BGN	CCN2	ENSSSCP00000029666	ENSSSCP00000037172	Biglycan; May be involved in collagen fiber assembly.	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	0.570
BGN	CD44	ENSSSCP00000029666	ENSSSCP00000014130	Biglycan; May be involved in collagen fiber assembly.	CD44 molecule (Indian blood group).	0.543
BGN	COL11A1	ENSSSCP00000029666	ENSSSCP00000072487	Biglycan; May be involved in collagen fiber assembly.	Collagen type XI alpha 1 chain.	0.446