STRINGSTRING
TUBB1 TUBB1 IL1B2 IL1B2 LOC110258578 LOC110258578 IL1A IL1A CD8B CD8B IFIT1 IFIT1 KIF11 KIF11 BUB3 BUB3 MYD88 MYD88 SH2D1A SH2D1A RELA RELA SERPING1 SERPING1 WEE1 WEE1 PLK5 PLK5 IRF1 IRF1 CDC25C CDC25C CD3E CD3E CHEK1 CHEK1 IL10 IL10 TLR3 TLR3 TRBV19 TRBV19 GZMK GZMK GZMA GZMA GZMA-2 GZMA-2 PLK2 PLK2 PTTG1 PTTG1 STAT3 STAT3 CDC6 CDC6 TOP2A TOP2A GP1BA GP1BA MCM3 MCM3 ISG20 ISG20 CLNK CLNK RPA3 RPA3 CCNB1 CCNB1 PLK1 PLK1 SOCS1 SOCS1 KIF22 KIF22 SERPINE1 SERPINE1 C5AR1 C5AR1 ICOS ICOS BMX BMX CD3D CD3D MX1 MX1 JAK2 JAK2 CFB CFB GGT1 GGT1 CDC45 CDC45 SLA-DMA SLA-DMA CTLA4 CTLA4 POLD2 POLD2 S100A12 S100A12 CXCL10 CXCL10 LOC110258125 LOC110258125 RAD51AP1 RAD51AP1 STAT1 STAT1 CD55 CD55 ITK ITK TNFRSF1A TNFRSF1A RELB RELB LEF1 LEF1 MYC MYC ITGB3 ITGB3 TREM1 TREM1 CD28 CD28 STAT2 STAT2 GZMB GZMB CDC7 CDC7 TLR2 TLR2 CCL4 CCL4 HBB HBB ORC6 ORC6 IFITM1 IFITM1 OAS1 OAS1 SLA-DQB1 SLA-DQB1 C4A C4A AURKB AURKB IRF9 IRF9 TLR4 TLR4 RIPK1 RIPK1 IL2 IL2 LOC110259156 LOC110259156 RPS20 RPS20 EIF2AK2 EIF2AK2 MX2 MX2 SLA-DRB1 SLA-DRB1 RPL32 RPL32 PLK4 PLK4 CLU CLU RPL13A RPL13A PKMYT1 PKMYT1 CENPE CENPE RSAD2 RSAD2 LOC110255300 LOC110255300 CDC25B CDC25B CASP3 CASP3 MCM4 MCM4 PIK3CG PIK3CG CENPM CENPM CD163 CD163 IL1B IL1B LOC110258579 LOC110258579 RPS5 RPS5 CDK1 CDK1 LCK LCK CD3G CD3G IL1B-2 IL1B-2 GZMM GZMM MAP3K1 MAP3K1 PCNA PCNA ISG15 ISG15 CD8A CD8A LOC110258582 LOC110258582 CCNB3 CCNB3 PSMB8 PSMB8 CFLAR CFLAR IFNG IFNG AURKA AURKA PARVB PARVB ESPL1 ESPL1 CD27 CD27 HLA-DRA HLA-DRA PSMB9 PSMB9 SLA-DMB SLA-DMB SLA-DOA SLA-DOA DAXX DAXX NFKBIE NFKBIE CCNE1 CCNE1 MTOR MTOR PLK3 PLK3 CCNB2 CCNB2 SERPINB2 SERPINB2 KIF23 KIF23
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC110258578Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
CD8BIg-like domain-containing protein. (260 aa)
IFIT1Interferon-stimulated protein 60. (509 aa)
KIF11Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1059 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa)
RELATranscription factor p65 isoform 1. (573 aa)
SERPING1Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa)
WEE1Wee1-like protein kinase. (646 aa)
PLK5Serine/threonine-protein kinase PLK. (611 aa)
IRF1Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (267 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
TRBV19T cell receptor beta variable 19. (127 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
GZMA-2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PTTG1Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. (1531 aa)
GP1BAPlatelet glycoprotein Ib alpha polypeptide. (627 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
ISG20Interferon stimulated exonuclease gene 20. (189 aa)
CLNKCytokine dependent hematopoietic cell linker. (446 aa)
RPA3Replication protein A3. (121 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
KIF22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (753 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ICOSIGv domain-containing protein. (209 aa)
BMXTyrosine-protein kinase. (706 aa)
CD3DT-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
CFBComplement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family. (851 aa)
GGT1Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] (617 aa)
CDC45Cell division cycle 45. (598 aa)
SLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (290 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
POLD2DNA polymerase delta 2, accessory subunit. (471 aa)
S100A12Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
CXCL10C-X-C motif chemokine. (104 aa)
LOC110258125Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RAD51AP1RAD51 associated protein 1. (345 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
CD55Uncharacterized protein. (609 aa)
ITKTyrosine-protein kinase. (598 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
TREM1Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). (252 aa)
CD28IGv domain-containing protein. (222 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
GZMBPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
CDC7Cell division cycle 7-related protein kinase isoform X1. (576 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (239 aa)
ORC6Origin recognition complex subunit 6. (287 aa)
IFITM1Uncharacterized protein. (147 aa)
OAS12'-5'-oligoadenylate synthase 1. (334 aa)
SLA-DQB1SLA class II histocompatibility antigen, DQ haplotype C beta chain. (271 aa)
C4AUncharacterized protein. (1758 aa)
AURKBAurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (443 aa)
IRF9IRF tryptophan pentad repeat domain-containing protein. (418 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
LOC110259156Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
RPS2040S ribosomal protein S20. (119 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
MX2Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
SLA-DRB1Ig-like domain-containing protein. (307 aa)
RPL3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
PLK4Polo like kinase 4. (964 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppres [...] (500 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (521 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2733 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
LOC110255300Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
CDC25BM-phase inducer phosphatase 2 isoform 1. (631 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
MCM4DNA helicase; Belongs to the MCM family. (882 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates [...] (1102 aa)
CENPMCentromere protein M. (162 aa)
CD163Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1113 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
LOC110258579Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
RPS540S ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (240 aa)
CDK1Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa)
LCKTyrosine-protein kinase. (520 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
IL1B-2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa)
GZMMPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (497 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
ISG15Ubiquitin-like modifier. (167 aa)
CD8ACD8a molecule. (237 aa)
LOC110258582Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1338 aa)
PSMB8Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adip [...] (295 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (509 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
AURKAAurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa)
PARVBParvin beta. (364 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2103 aa)
CD27CD27. (249 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa)
PSMB9Proteasome subunit beta. (219 aa)
SLA-DMBMajor histocompatibility complex, class II, DM beta. (272 aa)
SLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (360 aa)
DAXXDeath domain associated protein. (751 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (396 aa)
SERPINB2Plasminogen activator inhibitor 2; Belongs to the serpin family. (440 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (967 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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