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ACSL6 ACSL6 TKTL1 TKTL1 ACSL5 ACSL5 TKTL2 TKTL2 IDH1 IDH1 HKDC1 HKDC1 IDH2 IDH2 PKLR PKLR FH FH ENO1 ENO1 PKM PKM ACSL3 ACSL3 RPL32 RPL32 CS CS ACSL4 ACSL4 TALDO1 TALDO1 PLPP2 PLPP2 TKT TKT PLPP3 PLPP3 HK1 HK1 ME1 ME1 DGAT1 DGAT1 TPI1 TPI1 RPIA RPIA HK2 HK2 OGDH OGDH PLPP1 PLPP1 ACLY ACLY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACSL6Long-chain-fatty-acid--CoA ligase 6 isoform X1. (722 aa)
TKTL1Transketolase-like protein 1. (596 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (705 aa)
TKTL2Transketolase like 2. (589 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (463 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
IDH2Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. (452 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
PKMMultifunctional fusion protein; Belongs to the pyruvate kinase family. (1202 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (729 aa)
RPL3260S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
CSCitrate synthase, mitochondrial; Belongs to the citrate synthase family. (464 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (392 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
TKTTransketolase. (598 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
HK1Uncharacterized protein. (919 aa)
ME1NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)
DGAT1Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa)
TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (285 aa)
RPIARibose-5-phosphate isomerase; Belongs to the ribose 5-phosphate isomerase family. (306 aa)
HK2Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
OGDHOxoglutarate dehydrogenase. (1035 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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