STRINGSTRING
OAS1 OAS1 COL1A1 COL1A1 CALM3 CALM3 CALML4 CALML4 FMOD FMOD COL1A2 COL1A2 IL10 IL10 CSF2 CSF2 ELOVL5 ELOVL5 COL6A3 COL6A3 MX1 MX1 BGN BGN IL13 IL13 CAV1 CAV1 IL4 IL4 CALML5 CALML5 POSTN POSTN SFRP2 SFRP2 AREG AREG TAGLN2 TAGLN2 IFNB1 IFNB1 THBS1 THBS1 DCN DCN TAGLN3 TAGLN3 CXCL10 CXCL10 COL3A1 COL3A1 IFNG IFNG DOK6 DOK6 CXCL9 CXCL9 TAGLN TAGLN RSAD2 RSAD2 ALB ALB COL5A2 COL5A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OAS12'-5'-oligoadenylate synthase 1. (334 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
CALML4Uncharacterized protein. (154 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (325 aa)
COL6A3Collagen type VI alpha 3 chain. (2911 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
CALML5Calmodulin like 5. (149 aa)
POSTNPeriostin. (836 aa)
SFRP2Uncharacterized protein. (294 aa)
AREGAmphiregulin long form. (247 aa)
TAGLN2Transgelin; Belongs to the calponin family. (213 aa)
IFNB1Interferon-beta-1. (186 aa)
THBS1Uncharacterized protein. (1170 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
TAGLN3Transgelin-3. (217 aa)
CXCL10C-X-C motif chemokine. (104 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
DOK6Docking protein 6. (331 aa)
CXCL9C-X-C motif chemokine. (126 aa)
TAGLNTransgelin; Belongs to the calponin family. (239 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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