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| | RIPK1 | Receptor interacting serine/threonine kinase 1. (668 aa) |
| | DIRAS3 | GTP-binding RAS-like protein 3. (228 aa) |
| | HEXIM1 | HEXIM P-TEFb complex subunit 1. (348 aa) |
| | ARID5B | AT-rich interaction domain 5B. (1194 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2863 aa) |
| | RBM15 | RNA binding motif protein 15. (1006 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa) |
| | LUC7L | LUC7 like. (459 aa) |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa) |
| | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 isoform 1. (578 aa) |
| | DGCR8 | Microprocessor complex subunit DGCR8 isoform 1. (807 aa) |
| | PTEN | Uncharacterized protein. (576 aa) |
| | HELLS | Lymphoid-specific helicase isoform 1. (837 aa) |
| | NOL6 | Nucleolar protein 6. (1145 aa) |
| | DNAJA1 | DnaJ homolog subfamily A member 1 isoform 1. (397 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) |
| | RBM41 | RNA binding motif protein 41. (442 aa) |
| | CREBZF | CREB/ATF bZIP transcription factor isoform X1. (358 aa) |
| | RPUSD4 | RNA pseudouridylate synthase domain-containing protein 4. (376 aa) |
| | MDM4 | MDM4 regulator of p53. (506 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | DDX18 | RNA helicase. (786 aa) |
| | ID4 | DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). (161 aa) |
| | AKAP9 | A-kinase anchoring protein 9. (3930 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | EIF4E | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (496 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | LIFR | LIF receptor subunit alpha. (1170 aa) |
| | MX1 | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (820 aa) |
| | LARP4 | La ribonucleoprotein domain family member 4. (821 aa) |
| | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa) |
| | IFNAR2 | Uncharacterized protein. (574 aa) |
| | RBM5 | RNA binding motif protein 5. (893 aa) |
| | LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | STAT1 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | ATF7IP | Activating transcription factor 7 interacting protein. (1283 aa) |
| | NABP1 | Uncharacterized protein. (204 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | ABCA7 | ATP binding cassette subfamily A member 7. (2206 aa) |
| | LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) |
| | RHOQ | Rho-related GTP-binding protein RhoQ. (205 aa) |
| | ISG15 | Ubiquitin-like modifier. (167 aa) |
| | RNF2 | Ring finger protein 2. (368 aa) |
| | IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (855 aa) |
| | GNA14 | Guanine nucleotide-binding protein alpha 14. (355 aa) |
| | LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (603 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1130 aa) |
| | USP46 | Ubiquitin carboxyl-terminal hydrolase 46 isoform 1; Belongs to the peptidase C19 family. (366 aa) |
| | UBE2R2 | Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | PLAUR | Plasminogen activator, urokinase receptor. (330 aa) |
| | MX2 | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa) |
| | BCLAF1 | BCL2 associated transcription factor 1. (933 aa) |
| | ATXN1 | Ataxin-1 ATXN1. (821 aa) |
| | LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | FNBP1 | Formin binding protein 1. (616 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa) |
| | FUT8 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (581 aa) |
| | DNAJC11 | DnaJ heat shock protein family (Hsp40) member C11. (559 aa) |
