STRINGSTRING
RIPK1 RIPK1 DIRAS3 DIRAS3 HEXIM1 HEXIM1 ARID5B ARID5B IGF1R IGF1R CHD7 CHD7 RBM15 RBM15 JAG1 JAG1 LUC7L LUC7L IL1B2 IL1B2 LOC110258578 LOC110258578 IL1A IL1A CAMKK2 CAMKK2 DGCR8 DGCR8 PTEN PTEN HELLS HELLS NOL6 NOL6 DNAJA1 DNAJA1 PPARG PPARG RBM41 RBM41 CREBZF CREBZF RPUSD4 RPUSD4 MDM4 MDM4 IL10 IL10 GLI3 GLI3 CDC6 CDC6 DDX18 DDX18 ID4 ID4 AKAP9 AKAP9 TOP1 TOP1 IL6 IL6 EIF4E EIF4E MAP3K8 MAP3K8 TRIM27 TRIM27 LIFR LIFR MX1 MX1 JAK2 JAK2 FGFR2 FGFR2 LARP4 LARP4 TNFAIP3 TNFAIP3 ITGAV ITGAV IFNAR2 IFNAR2 RBM5 RBM5 LOC110258125 LOC110258125 STAT1 STAT1 SYK SYK ATF7IP ATF7IP NABP1 NABP1 PSMD12 PSMD12 CLDN1 CLDN1 ABCA7 ABCA7 LOC110258582 LOC110258582 RHOQ RHOQ ISG15 ISG15 RNF2 RNF2 IL1B-2 IL1B-2 FGFR3 FGFR3 GNA14 GNA14 LOC110258579 LOC110258579 INS INS IL1B IL1B TLE1 TLE1 BIRC3 BIRC3 USP28 USP28 USP46 USP46 UBE2R2 UBE2R2 LOC110255300 LOC110255300 PLAUR PLAUR MX2 MX2 BCLAF1 BCLAF1 ATXN1 ATXN1 LOC110259156 LOC110259156 YWHAG YWHAG FNBP1 FNBP1 PSMB9 PSMB9 NFKBIA NFKBIA FUT8 FUT8 DNAJC11 DNAJC11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
DIRAS3GTP-binding RAS-like protein 3. (228 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (348 aa)
ARID5BAT-rich interaction domain 5B. (1194 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2863 aa)
RBM15RNA binding motif protein 15. (1006 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
LUC7LLUC7 like. (459 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC110258578Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform 1. (578 aa)
DGCR8Microprocessor complex subunit DGCR8 isoform 1. (807 aa)
PTENUncharacterized protein. (576 aa)
HELLSLymphoid-specific helicase isoform 1. (837 aa)
NOL6Nucleolar protein 6. (1145 aa)
DNAJA1DnaJ homolog subfamily A member 1 isoform 1. (397 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
RBM41RNA binding motif protein 41. (442 aa)
CREBZFCREB/ATF bZIP transcription factor isoform X1. (358 aa)
RPUSD4RNA pseudouridylate synthase domain-containing protein 4. (376 aa)
MDM4MDM4 regulator of p53. (506 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
GLI3GLI family zinc finger 3. (1586 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
DDX18RNA helicase. (786 aa)
ID4DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). (161 aa)
AKAP9A-kinase anchoring protein 9. (3930 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (496 aa)
TRIM27Tripartite motif containing 27. (513 aa)
LIFRLIF receptor subunit alpha. (1170 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
LARP4La ribonucleoprotein domain family member 4. (821 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
IFNAR2Uncharacterized protein. (574 aa)
RBM5RNA binding motif protein 5. (893 aa)
LOC110258125Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
ATF7IPActivating transcription factor 7 interacting protein. (1283 aa)
NABP1Uncharacterized protein. (204 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ABCA7ATP binding cassette subfamily A member 7. (2206 aa)
LOC110258582Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa)
RHOQRho-related GTP-binding protein RhoQ. (205 aa)
ISG15Ubiquitin-like modifier. (167 aa)
RNF2Ring finger protein 2. (368 aa)
IL1B-2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
GNA14Guanine nucleotide-binding protein alpha 14. (355 aa)
LOC110258579Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1130 aa)
USP46Ubiquitin carboxyl-terminal hydrolase 46 isoform 1; Belongs to the peptidase C19 family. (366 aa)
UBE2R2Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
LOC110255300Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
PLAURPlasminogen activator, urokinase receptor. (330 aa)
MX2Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
BCLAF1BCL2 associated transcription factor 1. (933 aa)
ATXN1Ataxin-1 ATXN1. (821 aa)
LOC110259156Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
FNBP1Formin binding protein 1. (616 aa)
PSMB9Proteasome subunit beta. (219 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (581 aa)
DNAJC11DnaJ heat shock protein family (Hsp40) member C11. (559 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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