node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | PNLIP | ENSSSCP00000053712 | ENSSSCP00000011355 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Pancreatic triacylglycerol lipase. | 0.512 |
ALB | PNLIPRP1 | ENSSSCP00000053712 | ENSSSCP00000011357 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.510 |
ALB | PNLIPRP2 | ENSSSCP00000053712 | ENSSSCP00000050863 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.427 |
ALB | PNLIPRP3 | ENSSSCP00000053712 | ENSSSCP00000011354 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.515 |
ANGPTL4 | GPIHBP1 | ENSSSCP00000014452 | ENSSSCP00000036748 | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | 0.899 |
ANGPTL4 | LMF1 | ENSSSCP00000014452 | ENSSSCP00000034329 | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] | Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. | 0.568 |
ANGPTL4 | LPL | ENSSSCP00000014452 | ENSSSCP00000057312 | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. | 0.905 |
CLPS | GPIHBP1 | ENSSSCP00000001686 | ENSSSCP00000036748 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | 0.517 |
CLPS | PNLIP | ENSSSCP00000001686 | ENSSSCP00000011355 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Pancreatic triacylglycerol lipase. | 0.999 |
CLPS | PNLIPRP1 | ENSSSCP00000001686 | ENSSSCP00000011357 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.976 |
CLPS | PNLIPRP2 | ENSSSCP00000001686 | ENSSSCP00000050863 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.976 |
CLPS | PNLIPRP3 | ENSSSCP00000001686 | ENSSSCP00000011354 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.972 |
GPIHBP1 | ANGPTL4 | ENSSSCP00000036748 | ENSSSCP00000014452 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] | 0.899 |
GPIHBP1 | CLPS | ENSSSCP00000036748 | ENSSSCP00000001686 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. | 0.517 |
GPIHBP1 | LMF1 | ENSSSCP00000036748 | ENSSSCP00000034329 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. | 0.888 |
GPIHBP1 | LPL | ENSSSCP00000036748 | ENSSSCP00000057312 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. | 0.700 |
GPIHBP1 | PNLIPRP1 | ENSSSCP00000036748 | ENSSSCP00000011357 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.417 |
GPIHBP1 | PNLIPRP2 | ENSSSCP00000036748 | ENSSSCP00000050863 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.444 |
GPIHBP1 | PNLIPRP3 | ENSSSCP00000036748 | ENSSSCP00000011354 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.421 |
LMF1 | ANGPTL4 | ENSSSCP00000034329 | ENSSSCP00000014452 | Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] | 0.568 |