STRINGSTRING
CLDN4 CLDN4 SPI1 SPI1 RAG2 RAG2 RUNX3 RUNX3 CSF1R CSF1R NFE2L2 NFE2L2 C1QB C1QB RAG1 RAG1 AMZ1 AMZ1 SDR16C5 SDR16C5 TLR4 TLR4 CSF1 CSF1 C1QA C1QA TFEC TFEC CD40 CD40 SOCS3 SOCS3 CEP120 CEP120 CD74 CD74 MYOG MYOG CEBPB CEBPB LY86 LY86 CD163 CD163 STAB1 STAB1 IRF4 IRF4 PAX5 PAX5 P2RY13 P2RY13 TREM2 TREM2 RORC RORC NLRC5 NLRC5 LEF1 LEF1 STAT1 STAT1 GP91-PHOX GP91-PHOX TCF7 TCF7 CCR2 CCR2 CLEC5A CLEC5A CTSB CTSB CX3CR1 CX3CR1 LAPTM5 LAPTM5 BATF3 BATF3 CD4 CD4 GRB2 GRB2 FOXJ1 FOXJ1 TIMD4 TIMD4 HAVCR1 HAVCR1 DOCK2 DOCK2 SHH SHH ATF3 ATF3 NSL1 NSL1 PDGFRB PDGFRB IRF1 IRF1 ELF5 ELF5 P2RY12 P2RY12 MYD88 MYD88 LAMP1 LAMP1 CTSS CTSS LYN LYN DCSTAMP DCSTAMP CEBPA CEBPA PAX9 PAX9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
SPI1Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). (277 aa)
RAG2V(D)J recombination activating protein 2. (527 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (437 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
C1QBComplement C1q B chain. (295 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1049 aa)
AMZ1Uncharacterized protein. (498 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C, member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
CSF1Colony stimulating factor 1. (656 aa)
C1QAComplement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (266 aa)
TFECTranscription factor EC. (317 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
CEP120Centrosomal protein 120. (992 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
MYOGMyogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (215 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
LY86ML domain-containing protein. (197 aa)
CD163Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1113 aa)
STAB1Stabilin 1. (2684 aa)
IRF4Interferon regulatory factor 4. (451 aa)
PAX5Paired box 5. (390 aa)
P2RY13Purinergic receptor P2Y13; Belongs to the G-protein coupled receptor 1 family. (333 aa)
TREM2Ig-like domain-containing protein. (248 aa)
RORCRAR related orphan receptor C. (518 aa)
NLRC5NLR family CARD domain containing 5. (1846 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
GP91-PHOXCytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. (569 aa)
TCF7Transcription factor 7. (484 aa)
CCR2C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. (373 aa)
CLEC5AC-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). (185 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
CX3CR1CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LAPTM5Lysosomal protein transmembrane 5. (264 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (122 aa)
CD4CD4 molecule. (494 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
FOXJ1Forkhead box J1. (421 aa)
TIMD4T cell immunoglobulin and mucin domain containing 4. (361 aa)
HAVCR1Hepatitis A virus cellular receptor 1 isoform X1. (349 aa)
DOCK2Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa)
NSL1NSL1 component of MIS12 kinetochore complex. (290 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
IRF1Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa)
ELF5ETS-related transcription factor Elf-5 isoform 2. (255 aa)
P2RY12Purinergic receptor P2Y12. (339 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
LAMP1Uncharacterized protein. (413 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
LYNTyrosine-protein kinase. (512 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (487 aa)
CEBPACCAAT/enhancer-binding protein alpha isoform c. (354 aa)
PAX9Paired box 9. (394 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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