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CDKN1A CDKN1A CEBPE CEBPE ARG2 ARG2 AARS1 AARS1 SARS2 SARS2 SLC1A5 SLC1A5 FGF21 FGF21 ATF5 ATF5 ACTC1 ACTC1 PSAT1 PSAT1 SLC7A1 SLC7A1 CAST CAST ASNS ASNS MYL4 MYL4 YARS1 YARS1 IARS1 IARS1 SLC3A2 SLC3A2 TNNT2 TNNT2 PSPH PSPH PRKACA PRKACA CHAC1 CHAC1 ASS1 ASS1 CEBPG CEBPG PYGL PYGL CEBPB CEBPB XBP1 XBP1 AARS2 AARS2 PYGM PYGM SARS1 SARS1 ATF4 ATF4 GADD45A GADD45A PRKACB PRKACB ATF6 ATF6 GPT2 GPT2 PHGDH PHGDH SESN2 SESN2 PYCR1 PYCR1 PYGB PYGB TNNT1 TNNT1 MYH7 MYH7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
CEBPECCAAT/enhancer-binding protein. (282 aa)
ARG2Arginase. (354 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (967 aa)
SARS2AA_TRNA_LIGASE_II domain-containing protein. (521 aa)
SLC1A5Amino acid transporter. (541 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATF5Activating transcription factor 5. (282 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
PSAT1Phosphoserine aminotransferase. (376 aa)
SLC7A1Cationic amino acid transporter-1. (629 aa)
CASTCalpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. (835 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (545 aa)
MYL4Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. (197 aa)
YARS1Tyrosine--tRNA ligase. (528 aa)
IARS1Isoleucine--tRNA ligase, cytoplasmic isoform X1; Belongs to the class-I aminoacyl-tRNA synthetase family. (1262 aa)
SLC3A2Solute carrier family 3 member 2. (562 aa)
TNNT2Uncharacterized protein. (295 aa)
PSPHPhosphoserine phosphatase isoform X1. (225 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa)
ASS1Argininosuccinate synthase 1. (428 aa)
CEBPGCCAAT enhancer binding protein gamma. (164 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
XBP1BZIP domain-containing protein. (378 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1014 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa)
SARS1Seryl-tRNA synthetase. (537 aa)
ATF4Activating transcription factor 4. (329 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (184 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
ATF6Activating transcription factor 6. (680 aa)
GPT2Glutamic--pyruvic transaminase 2. (547 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (547 aa)
SESN2Sestrin 2. (471 aa)
PYCR1Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (385 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
TNNT1Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (298 aa)
MYH7Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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