STRINGSTRING
ACTA1 ACTA1 ACTC1 ACTC1 COL5A1 COL5A1 COX5B COX5B PPP1R3C PPP1R3C NEURL1 NEURL1 CSRP3 CSRP3 NDUFA13 NDUFA13 COL1A2 COL1A2 MAPKAPK2 MAPKAPK2 ANXA6 ANXA6 AKAP9 AKAP9 SCN4B SCN4B CTSB CTSB BGN BGN ATP5F1E ATP5F1E GRB10 GRB10 TNNI1 TNNI1 COL3A1 COL3A1 STK40 STK40 SPEG SPEG CCN2 CCN2 ELOVL6 ELOVL6 KCNJ12 KCNJ12 HPRT1 HPRT1 MAPK6 MAPK6 ATP2A1 ATP2A1 COX7A1 COX7A1 ATP5PD ATP5PD B2M B2M CD74 CD74 PYGM PYGM TEAD4 TEAD4 COL5A2 COL5A2 MYLK2 MYLK2 KCNJ11 KCNJ11 COL14A1 COL14A1 COL1A1 COL1A1 TIMP2 TIMP2 DEPTOR DEPTOR RXRA RXRA ARID5B ARID5B HSPA6 HSPA6 ACTN3 ACTN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTA1Actin, alpha skeletal muscle. (465 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
COX5BCytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (129 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (638 aa)
CSRP3Uncharacterized protein. (200 aa)
NDUFA13Uncharacterized protein. (144 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
ANXA6Annexin. (672 aa)
AKAP9A-kinase anchoring protein 9. (3930 aa)
SCN4BIg-like domain-containing protein. (480 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
ATP5F1EUncharacterized protein. (136 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
TNNI1Troponin I1, slow skeletal type. (228 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
STK40Serine/threonine-protein kinase 40 isoform 2. (435 aa)
SPEGUncharacterized protein. (869 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12 isoform X1. (429 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (224 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa)
COX7A1Cytochrome c oxidase subunit 7A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] (80 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (170 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (157 aa)
CD74Thyroglobulin type-1 domain-containing protein. (347 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (497 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
MYLK2Myosin light chain kinase 2. (652 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (388 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
TIMP2Uncharacterized protein. (257 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform 1. (409 aa)
RXRARetinoid X receptor alpha. (701 aa)
ARID5BAT-rich interaction domain 5B. (1194 aa)
HSPA6Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (931 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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