STRINGSTRING
TFE3 TFE3 CHMP2B CHMP2B ATG3 ATG3 ARL8B ARL8B FYCO1 FYCO1 SNAP29 SNAP29 LAMP1 LAMP1 ATG14 ATG14 VAC14 VAC14 STX7 STX7 ATG5 ATG5 INPP5E INPP5E VAPA VAPA VAPB VAPB WIPI2 WIPI2 ATG12 ATG12 LAMP2 LAMP2 EI24 EI24 ATG7 ATG7 VAMP7 VAMP7 STX17 STX17 UVRAG UVRAG YKT6 YKT6 EPG5 EPG5 RABIF RABIF FIG4 FIG4 VAMP8 VAMP8 ATG10 ATG10 GABARAP GABARAP CCZ1 CCZ1 BECN1 BECN1 PLEKHM1 PLEKHM1 ATG13 ATG13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
ATG3Autophagy-related protein 3. (320 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (224 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1444 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
LAMP1Uncharacterized protein. (413 aa)
ATG14Autophagy related 14. (510 aa)
VAC14Protein VAC14 homolog isoform 1. (783 aa)
STX7Syntaxin 7. (262 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (287 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (829 aa)
VAPAVAMP associated protein A. (303 aa)
VAPBVesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (559 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa)
EI24EI24 autophagy associated transmembrane protein. (262 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (710 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (258 aa)
STX17Syntaxin-17 isoform X1; Belongs to the syntaxin family. (302 aa)
UVRAGUV radiation resistance associated. (748 aa)
YKT6Uncharacterized protein; Belongs to the synaptobrevin family. (221 aa)
EPG5Ectopic P-granules autophagy protein 5 homolog. (2577 aa)
RABIFRAB interacting factor. (123 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (915 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (143 aa)
ATG10Autophagy related 10. (330 aa)
GABARAPUncharacterized protein. (98 aa)
CCZ1Uncharacterized protein. (482 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
PLEKHM1Pleckstrin homology domain-containing family M member 1 isoform X1. (1048 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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