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GATA6 GATA6 ANXA1 ANXA1 MUC1 MUC1 ANXA9 ANXA9 ANXA4 ANXA4 ANXA5 ANXA5 NKX6-1 NKX6-1 MUC13 MUC13 UPK1B UPK1B SHH SHH ANXA6 ANXA6 SOX9 SOX9 ANXA7 ANXA7 PTF1A PTF1A GATA4 GATA4 ANXA11 ANXA11 ANXA2 ANXA2 CFTR CFTR ANXA13 ANXA13 CPA1 CPA1 KRT8 KRT8 MUC4 MUC4 KRT14 KRT14 ANXA8 ANXA8 UPK1A UPK1A PLA2G1B PLA2G1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
MUC1SEA domain-containing protein. (638 aa)
ANXA9Annexin. (360 aa)
ANXA4Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family. (337 aa)
ANXA5Annexin. (321 aa)
NKX6-1NK6 homeobox 1. (370 aa)
MUC13Uncharacterized protein. (537 aa)
UPK1BTetraspanin. (259 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
ANXA6Annexin. (672 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
ANXA7Annexin. (485 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
ANXA11Annexin. (516 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa)
ANXA13Annexin. (357 aa)
CPA1Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. (635 aa)
KRT8Keratin, type II cytoskeletal 8 isoform 2; Belongs to the intermediate filament family. (461 aa)
MUC4Uncharacterized protein. (1173 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (515 aa)
ANXA8Annexin. (354 aa)
UPK1AUncharacterized protein; Belongs to the tetraspanin (TM4SF) family. (284 aa)
PLA2G1BPhospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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