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EIF4A3 EIF4A3 MXD3 MXD3 USP26 USP26 ELF4 ELF4 BCORL1 BCORL1 BEX1 BEX1 HUWE1 HUWE1 KDM5C KDM5C UBA1 UBA1 DDX3X DDX3X NR0B1 NR0B1 MSL2 MSL2 CYP17A1 CYP17A1 MSX1 MSX1 SF3B6 SF3B6 MXD1 MXD1 SNRNP25 SNRNP25 CD2BP2 CD2BP2 HSD3B1 HSD3B1 SETX SETX SCMH1 SCMH1 PPIH PPIH WNT4 WNT4 SOX5 SOX5 SNRPF SNRPF EXOSC6 EXOSC6 MAGOH MAGOH IRX3 IRX3 SNRPA SNRPA TAB3 TAB3 RSRC1 RSRC1 AMHR2 AMHR2 DDX4 DDX4 LSM4 LSM4 PTGDS PTGDS ZRSR2 ZRSR2 EMD EMD HDAC9 HDAC9 POLA1 POLA1 FOXL2 FOXL2 KDM5D KDM5D LSM7 LSM7 HDAC4 HDAC4 LSM3 LSM3 HDAC7 HDAC7 FGF9 FGF9 SOX13 SOX13 ALPL ALPL CWC15 CWC15 AMH AMH SON SON COX7B COX7B NANOG NANOG MXI1 MXI1 ZMAT5 ZMAT5 FLNA FLNA DOCK9 DOCK9 PCGF5 PCGF5 RSPO1 RSPO1 ENO1 ENO1 GRIK3 GRIK3 JARID2 JARID2 RBBP4 RBBP4 U2AF1 U2AF1 U2AF2 U2AF2 SOX6 SOX6 CLCN5 CLCN5 SH3D21 SH3D21 SF3A1 SF3A1 SHROOM4 SHROOM4 TSPAN33 TSPAN33 XIAP XIAP KHDRBS2 KHDRBS2 KDM3A KDM3A SRSF5 SRSF5 SOX10 SOX10 SOX8 SOX8 XPO1 XPO1 RBM5 RBM5 CTNNB1 CTNNB1 PHF5A PHF5A TGFBR1 TGFBR1 FMR1 FMR1 AMOT AMOT FGFR2 FGFR2 KDM6A KDM6A MBNL3 MBNL3 RPL39 RPL39 GADD45G GADD45G GATA4 GATA4 CBX2 CBX2 LOC106504154 LOC106504154 KPNA2 KPNA2 SMNDC1 SMNDC1 TAF1 TAF1 MXD4 MXD4 SRY SRY CYP11A1 CYP11A1 PPP1R8 PPP1R8 LOC100624590 LOC100624590 CHTF18 CHTF18 SNW1 SNW1 PRPF8 PRPF8 MED1 MED1 HDAC5 HDAC5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
MXD3MAX dimerization protein 3. (206 aa)
USP26Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (904 aa)
ELF4E74-like factor 4 (Ets domain transcription factor). (662 aa)
BCORL1BCL6 corepressor like 1. (1786 aa)
BEX1Uncharacterized protein. (129 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4415 aa)
KDM5CLysine-specific demethylase 5C; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). (1516 aa)
UBA1Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1018 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (490 aa)
MSL2E3 ubiquitin-protein ligase MSL2 isoform 1. (577 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa)
MSX1Homeobox domain-containing protein. (303 aa)
SF3B6Splicing factor 3B subunit 6. (125 aa)
MXD1MAX dimerization protein 1. (221 aa)
SNRNP25Small nuclear ribonucleoprotein U11/U12 subunit 25. (132 aa)
CD2BP2CD2 cytoplasmic tail binding protein 2. (369 aa)
HSD3B13 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (373 aa)
SETXSenataxin. (2676 aa)
SCMH1Scm polycomb group protein homolog 1. (647 aa)
PPIHPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SOX5SRY-box transcription factor 5. (763 aa)
SNRPFSm domain-containing protein. (86 aa)
EXOSC6Exosome component 6. (272 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
IRX3Iroquois-class homeodomain protein IRX-3 isoform X2. (502 aa)
SNRPAU1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). (281 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
RSRC1Arginine and serine rich coiled-coil 1. (334 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
DDX4Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycl [...] (744 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (234 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (297 aa)
ZRSR2U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2. (479 aa)
EMDLEM domain-containing protein. (400 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
POLA1DNA polymerase. (1652 aa)
FOXL2Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1- mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates [...] (270 aa)
KDM5DLysine demethylase 5D. (1506 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (150 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (105 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (980 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
SOX13SRY-box transcription factor 13. (676 aa)
ALPLAlkaline phosphatase. (834 aa)
CWC15CWC15 spliceosome associated protein homolog. (254 aa)
AMHMuellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). (577 aa)
SONSON DNA binding protein. (2447 aa)
COX7BCytochrome c oxidase subunit 7B, mitochondrial. (80 aa)
NANOGHomeobox domain-containing protein. (304 aa)
MXI1MAX interactor 1, dimerization protein. (281 aa)
ZMAT5Zinc finger matrin-type protein 5. (170 aa)
FLNAFilamin A. (2897 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2290 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
RSPO1R-spondin 1. (262 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (999 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1245 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (427 aa)
U2AF1Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). (239 aa)
U2AF2U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
SOX6SRY-box transcription factor 6. (859 aa)
CLCN5H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). (816 aa)
SH3D21SH3 domain-containing protein. (548 aa)
SF3A1Splicing factor 3a subunit 1. (722 aa)
SHROOM4Shroom family member 4. (1564 aa)
TSPAN33Tetraspanin. (310 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (349 aa)
KDM3ALysine demethylase 3A. (1323 aa)
SRSF5Serine and arginine rich splicing factor 5. (271 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
SOX8SRY-box transcription factor 8. (460 aa)
XPO1Exportin 1. (1071 aa)
RBM5RNA binding motif protein 5. (893 aa)
CTNNB1Catenin beta 1. (808 aa)
PHF5APHD finger protein 5A. (139 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
FMR1Fragile X mental retardation protein 1. (632 aa)
AMOTAngiomotin isoform X1. (1088 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
KDM6ALysine demethylase 6A. (1400 aa)
MBNL3Muscleblind like splicing regulator 3. (369 aa)
RPL39Uncharacterized protein. (51 aa)
GADD45GGrowth arrest and DNA-damage-inducible gamma protein. (159 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
CBX2Chromobox protein homolog 2 isoform X1. (531 aa)
LOC106504154Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (236 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
SMNDC1Survival motor neuron domain containing 1. (278 aa)
TAF1Transcription initiation factor TFIID subunit. (2001 aa)
MXD4MAX dimerization protein 4. (209 aa)
SRYSex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity). (236 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...] (520 aa)
PPP1R8Protein phosphatase 1 regulatory subunit 8. (351 aa)
LOC100624590ATP-dependent RNA helicase DDX3X isoform 2; Belongs to the DEAD box helicase family. (670 aa)
CHTF18Chromosome transmission fidelity factor 18. (942 aa)
SNW1SNW domain-containing protein 1 isoform 2. (536 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1131 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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