| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP4A | SST | ENSSSCP00000069966 | ENSSSCP00000051543 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.458 |
| CCK | CTRB2 | ENSSSCP00000012023 | ENSSSCP00000024109 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.435 |
| CCK | INS | ENSSSCP00000012023 | ENSSSCP00000044635 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.784 |
| CCK | LOC100621820 | ENSSSCP00000012023 | ENSSSCP00000023533 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.448 |
| CCK | LOC100739735 | ENSSSCP00000012023 | ENSSSCP00000051113 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.448 |
| CCK | SCT | ENSSSCP00000012023 | ENSSSCP00000034067 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] | 0.878 |
| CCK | SST | ENSSSCP00000012023 | ENSSSCP00000051543 | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.958 |
| CELA2A | CTRL | ENSSSCP00000065549 | ENSSSCP00000021733 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.461 |
| CELA2A | PNLIP | ENSSSCP00000065549 | ENSSSCP00000011355 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Pancreatic triacylglycerol lipase. | 0.572 |
| CELA2A | PNLIPRP1 | ENSSSCP00000065549 | ENSSSCP00000011357 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.582 |
| CFTR | INS | ENSSSCP00000036792 | ENSSSCP00000044635 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.448 |
| CFTR | LOC100302368 | ENSSSCP00000036792 | ENSSSCP00000045861 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Trypsin. | 0.670 |
| CFTR | SCT | ENSSSCP00000036792 | ENSSSCP00000034067 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] | 0.408 |
| CTRB2 | CCK | ENSSSCP00000024109 | ENSSSCP00000012023 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. | 0.435 |
| CTRB2 | INS | ENSSSCP00000024109 | ENSSSCP00000044635 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.455 |
| CTRB2 | LOC100302368 | ENSSSCP00000024109 | ENSSSCP00000045861 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Trypsin. | 0.476 |
| CTRB2 | LOC100621820 | ENSSSCP00000024109 | ENSSSCP00000023533 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.902 |
| CTRB2 | LOC100739735 | ENSSSCP00000024109 | ENSSSCP00000051113 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.903 |
| CTRB2 | PNLIP | ENSSSCP00000024109 | ENSSSCP00000011355 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Pancreatic triacylglycerol lipase. | 0.788 |
| CTRB2 | PNLIPRP1 | ENSSSCP00000024109 | ENSSSCP00000011357 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.787 |