STRINGSTRING
PRKACB PRKACB MME MME SLC5A1 SLC5A1 GRK5 GRK5 CALML5 CALML5 ADM ADM PRPSAP2 PRPSAP2 TSC2 TSC2 RGS19 RGS19 RGS10 RGS10 RGS13 RGS13 REN REN IL1B IL1B RGS8 RGS8 RGS7 RGS7 TXN2 TXN2 RGS2 RGS2 BRD4 BRD4 RGS18 RGS18 PRKACA PRKACA RXFP1 RXFP1 RGS21 RGS21 ARRB1 ARRB1 RGS1 RGS1 ACE2 ACE2 IL6 IL6 PDE9A PDE9A HDAC5 HDAC5 ACE ACE GCG GCG RGS6 RGS6 HDAC7 HDAC7 HDAC4 HDAC4 TRPC6 TRPC6 GRK2 GRK2 RGS5 RGS5 HDAC9 HDAC9 APLN APLN RYR2 RYR2 CALML4 CALML4 IL18 IL18 PDE1C PDE1C CALM3 CALM3 MMEL1 MMEL1 LOC100515049 LOC100515049 RGS3 RGS3 RGS16 RGS16 PDE1A PDE1A ARRB2 ARRB2 TXN TXN TTN TTN SRF SRF HCN4 HCN4 NPPA NPPA RGS17 RGS17 RGS20 RGS20 RGS4 RGS4 IL1B2 IL1B2 RGS12 RGS12
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
SLC5A1Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (690 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
CALML5Calmodulin like 5. (149 aa)
ADMProadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. (188 aa)
PRPSAP2Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (876 aa)
TSC2TSC complex subunit 2. (1836 aa)
RGS19Regulator of G protein signaling 19. (302 aa)
RGS10Regulator of G protein signaling 10. (173 aa)
RGS13Regulator of G protein signaling 13. (182 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
RGS8Regulator of G protein signaling 8. (236 aa)
RGS7Regulator of G-protein signaling 7 isoform 3. (500 aa)
TXN2Thioredoxin 2. (255 aa)
RGS2Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF [...] (212 aa)
BRD4Bromodomain containing 4. (1373 aa)
RGS18Regulator of G-protein signaling 18. (235 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
RGS21Regulator of G protein signaling 21. (152 aa)
ARRB1Arrestin beta 1. (607 aa)
RGS1Regulator of G-protein signaling 1. (209 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
PDE9APhosphodiesterase. (565 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1131 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
RGS6Regulator of G protein signaling 6. (516 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (980 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (939 aa)
GRK2G protein-coupled receptor kinase 2. (778 aa)
RGS5Regulator of G-protein signaling 5; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). (206 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
APLNApelin. (77 aa)
RYR2Ryanodine receptor 2. (4966 aa)
CALML4Uncharacterized protein. (154 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa)
PDE1CPhosphodiesterase. (785 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
MMEL1Membrane metalloendopeptidase like 1. (837 aa)
LOC100515049Angiotensin-converting enzyme. (771 aa)
RGS3Regulator of G protein signaling 3. (913 aa)
RGS16Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. (274 aa)
PDE1APhosphodiesterase. (545 aa)
ARRB2Arrestin beta 2. (493 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (169 aa)
TTNUncharacterized protein. (563 aa)
SRFSerum response factor. (512 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1199 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
RGS17Regulator of G-protein signaling 17. (210 aa)
RGS20Regulator of G protein signaling 20. (374 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
RGS12Regulator of G protein signaling 12. (1441 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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