STRINGSTRING
PODN PODN NAV3 NAV3 ALDH1A1 ALDH1A1 EGF EGF TAB1 TAB1 BGN BGN NCAM1 NCAM1 NCDN NCDN AHNAK2 AHNAK2 BMP2 BMP2 NAV1 NAV1 MYOC MYOC RLBP1 RLBP1 NFASC NFASC TSPO2 TSPO2 CRYAB CRYAB SLC25A6 SLC25A6 PRELP PRELP NEFL NEFL AQP1 AQP1 TLR4 TLR4 MBP MBP MGP MGP AHNAK-2 AHNAK-2 IMPG1 IMPG1 HSPA6 HSPA6 TSPO TSPO LUM LUM SRSF3 SRSF3 FBLN5 FBLN5 CNTLN CNTLN NBAS NBAS HTT HTT RBP3 RBP3 RHO RHO CD44 CD44 CALR CALR CALR3 CALR3 RELN RELN NCL NCL AOC2 AOC2 P3H1 P3H1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PODNLRRNT domain-containing protein. (697 aa)
NAV3Neuron navigator 3. (2383 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (604 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
NCAM1Neural cell adhesion molecule 1. (1140 aa)
NCDNNeurochondrin. (712 aa)
AHNAK2PDZ domain-containing protein. (3819 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
NAV1Neuron navigator 1. (2165 aa)
MYOCMyocilin. (489 aa)
RLBP1Retinaldehyde binding protein 1. (384 aa)
NFASCNeurofascin. (1587 aa)
TSPO2Translocator protein 2. (171 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (237 aa)
SLC25A6ADP/ATP translocase 3, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). (355 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
NEFLNeurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. (560 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (295 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
AHNAK-2PDZ domain-containing protein. (227 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1. (787 aa)
HSPA6Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa)
TSPOTranslocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (By similarity); Belongs to the TspO/BZRP family. (169 aa)
LUMLumican. (341 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
FBLN5Fibulin-5 isoform X2. (461 aa)
CNTLNCentlein. (1378 aa)
NBASNeuroblastoma amplified sequence. (2318 aa)
HTTHuntingtin. (3138 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1284 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa)
CALR3Calreticulin. (384 aa)
RELNReelin. (3458 aa)
NCLZinc finger protein Pegasus. (724 aa)
AOC2Amine oxidase. (755 aa)
P3H1Prolyl 3-hydroxylase 1 isoform 1. (698 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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