14 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WTAP	Uncharacterized protein. (649 aa)
	METTL14	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (874 aa)
	XRN1	5'-3' exoribonuclease 1. (1703 aa)
	METTL4	Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa)
	VIRMA	Vir like m6A methyltransferase associated. (1812 aa)
	RBM15	RNA binding motif protein 15. (1006 aa)
	NXT1	Nuclear transport factor 2 like export factor 1. (140 aa)
	H2AFZ	Histone H2A; Belongs to the histone H2A family. (128 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
	RBM15B	RNA binding motif protein 15B. (854 aa)
	DROSHA	Drosha ribonuclease III. (1397 aa)
	N6AMT1	N-6 adenine-specific DNA methyltransferase 1. (220 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DROSHA	ENSSSCP00000059624	ENSSSCP00000017805	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.948
AGO2	H2AFZ	ENSSSCP00000059624	ENSSSCP00000009788	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Histone H2A; Belongs to the histone H2A family.	0.518
AGO2	XRN1	ENSSSCP00000059624	ENSSSCP00000067024	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	5'-3' exoribonuclease 1.	0.540
ALKBH5	METTL14	ENSSSCP00000038766	ENSSSCP00000046701	AlkB homolog 5, RNA demethylase.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.953
ALKBH5	METTL4	ENSSSCP00000038766	ENSSSCP00000068190	AlkB homolog 5, RNA demethylase.	Methyltransferase like 4; Belongs to the MT-A70-like family.	0.678
ALKBH5	N6AMT1	ENSSSCP00000038766	ENSSSCP00000020458	AlkB homolog 5, RNA demethylase.	N-6 adenine-specific DNA methyltransferase 1.	0.489
ALKBH5	RBM15	ENSSSCP00000038766	ENSSSCP00000007262	AlkB homolog 5, RNA demethylase.	RNA binding motif protein 15.	0.853
ALKBH5	RBM15B	ENSSSCP00000038766	ENSSSCP00000012172	AlkB homolog 5, RNA demethylase.	RNA binding motif protein 15B.	0.817
ALKBH5	VIRMA	ENSSSCP00000038766	ENSSSCP00000006511	AlkB homolog 5, RNA demethylase.	Vir like m6A methyltransferase associated.	0.828
ALKBH5	WTAP	ENSSSCP00000038766	ENSSSCP00000039764	AlkB homolog 5, RNA demethylase.	Uncharacterized protein.	0.975
DROSHA	AGO2	ENSSSCP00000017805	ENSSSCP00000059624	Drosha ribonuclease III.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.948
DROSHA	XRN1	ENSSSCP00000017805	ENSSSCP00000067024	Drosha ribonuclease III.	5'-3' exoribonuclease 1.	0.616
H2AFZ	AGO2	ENSSSCP00000009788	ENSSSCP00000059624	Histone H2A; Belongs to the histone H2A family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.518
H2AFZ	MYD88	ENSSSCP00000009788	ENSSSCP00000011996	Histone H2A; Belongs to the histone H2A family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.474
METTL14	ALKBH5	ENSSSCP00000046701	ENSSSCP00000038766	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	AlkB homolog 5, RNA demethylase.	0.953
METTL14	METTL4	ENSSSCP00000046701	ENSSSCP00000068190	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	Methyltransferase like 4; Belongs to the MT-A70-like family.	0.855
METTL14	N6AMT1	ENSSSCP00000046701	ENSSSCP00000020458	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	N-6 adenine-specific DNA methyltransferase 1.	0.660
METTL14	RBM15	ENSSSCP00000046701	ENSSSCP00000007262	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	RNA binding motif protein 15.	0.994
METTL14	RBM15B	ENSSSCP00000046701	ENSSSCP00000012172	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	RNA binding motif protein 15B.	0.931
METTL14	VIRMA	ENSSSCP00000046701	ENSSSCP00000006511	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	Vir like m6A methyltransferase associated.	0.997