STRINGSTRING
WTAP WTAP METTL14 METTL14 AGO2 AGO2 XRN1 XRN1 METTL4 METTL4 VIRMA VIRMA RBM15 RBM15 NXT1 NXT1 H2AFZ H2AFZ MYD88 MYD88 RBM15B RBM15B DROSHA DROSHA N6AMT1 N6AMT1 ALKBH5 ALKBH5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WTAPUncharacterized protein. (649 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (874 aa)
XRN15'-3' exoribonuclease 1. (1703 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
RBM15RNA binding motif protein 15. (1006 aa)
NXT1Nuclear transport factor 2 like export factor 1. (140 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
RBM15BRNA binding motif protein 15B. (854 aa)
DROSHADrosha ribonuclease III. (1397 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (220 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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