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PRRC2A PRRC2A PDIA3 PDIA3 PPIF PPIF CCDC86 CCDC86 CYCS CYCS HNRNPH1 HNRNPH1 COX5A COX5A EEF2 EEF2 LOC100519295 LOC100519295 EEF1D EEF1D NPM1 NPM1 EEF1A1 EEF1A1 TRIM28 TRIM28 HNRNPU HNRNPU GAPDH GAPDH HSPA8 HSPA8 H1-4 H1-4 PGAM1 PGAM1 HNRNPL HNRNPL ALB ALB HSPA5 HSPA5 MYL6 MYL6 H1-3 H1-3 TCOF1 TCOF1 ALYREF ALYREF HSPA6 HSPA6 TPM3 TPM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRRC2ABAT2_N domain-containing protein. (2166 aa)
PDIA3Protein disulfide-isomerase. (504 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (237 aa)
CCDC86Uncharacterized protein. (527 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HNRNPH1Heterogeneous nuclear ribonucleoprotein H1. (486 aa)
COX5ACytochrome c oxidase subunit 5A, mitochondrial. (152 aa)
EEF2Eukaryotic translation elongation factor 2. (863 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
EEF1DEukaryotic translation elongation factor 1 delta. (686 aa)
NPM1Nucleophosmin isoform 1. (294 aa)
EEF1A1Eukaryotic translation elongation factor 1 alpha 1. (502 aa)
TRIM28Tripartite motif containing 28. (868 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (680 aa)
H1-4Histone cluster 1 H1 family member e. (207 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
HNRNPLHeterogeneous nuclear ribonucleoprotein L. (454 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa)
MYL6Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (278 aa)
H1-3Histone H2B; Belongs to the histone H2B family. (322 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1399 aa)
ALYREFAly/REF export factor. (348 aa)
HSPA6Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa)
TPM3Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (303 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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