50 items (Sus scrofa) - STRING interaction network

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	CA2	Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (305 aa)
	COL5A1	Fibrillar collagen NC1 domain-containing protein. (1918 aa)
	ANXA9	Annexin. (360 aa)
	AMTN	Amelotin. (209 aa)
	ANXA5	Annexin. (321 aa)
	CTSL	Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family. (332 aa)
	CTSV	Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
	COL7A1	Uncharacterized protein. (2938 aa)
	ACPP	Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (413 aa)
	PGK1	Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
	COL5A3	Collagen type V alpha 3 chain. (1747 aa)
	MMP20	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity). (483 aa)
	MMP1	Stromelysin-1 preproprotein. (477 aa)
	LAMC2	Laminin subunit gamma-2 isoform a. (1191 aa)
	ANXA6	Annexin. (672 aa)
	JUP	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
	KLK4	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa)
	DSG1	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). (1045 aa)
	ANXA7	Annexin. (485 aa)
	COL17A1	Collagen type XVII alpha 1 chain. (1506 aa)
	RETN	Resistin. (109 aa)
	ANXA11	Annexin. (516 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	PGLYRP1	20 kDa neutrophil cationic protein. (222 aa)
	ANXA2	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1471 aa)
	SERPINH1	SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
	ANXA13	Annexin. (357 aa)
	GSN	Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Belongs to the villin/gelsolin family. (780 aa)
	SCIN	Adseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
	PGK2	Phosphoglycerate kinase 2; Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Belongs to the phosphoglycerate kinase family. (417 aa)
	ACP4	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family. (450 aa)
	PKM	Multifunctional fusion protein; Belongs to the pyruvate kinase family. (1202 aa)
	GJA1	Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
	AHSG	Alpha-2-HS-glycoprotein. (394 aa)
	COL5A2	Collagen alpha-2(V) chain preproprotein. (1499 aa)
	LCN2	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (314 aa)
	ALPL	Alkaline phosphatase. (834 aa)
	ANXA8	Annexin. (354 aa)
	ENAM	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. (1142 aa)
	MGP	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
	ITGB4	Integrin beta. (1814 aa)
	AMELY	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (189 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)
	NTS	Neurotensin/neuromedin N preproprotein. (171 aa)
	LAMA3	Laminin subunit alpha 3. (3345 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP4	AMELY	ENSSSCP00000050186	ENSSSCP00000072463	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.552
ACP4	AMTN	ENSSSCP00000050186	ENSSSCP00000009535	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	Amelotin.	0.706
ACP4	COL17A1	ENSSSCP00000050186	ENSSSCP00000027778	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	Collagen type XVII alpha 1 chain.	0.462
ACP4	ENAM	ENSSSCP00000050186	ENSSSCP00000063311	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.716
ACP4	KLK4	ENSSSCP00000050186	ENSSSCP00000019614	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family.	0.721
ACP4	MMP20	ENSSSCP00000050186	ENSSSCP00000015906	Testicular acid phosphatase; Belongs to the histidine acid phosphatase family.	Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity).	0.585
ACPP	DSG1	ENSSSCP00000012390	ENSSSCP00000020931	Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.424
ACPP	ENAM	ENSSSCP00000012390	ENSSSCP00000063311	Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family.	142 kDa enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.	0.469
AHSG	ALB	ENSSSCP00000054117	ENSSSCP00000053712	Alpha-2-HS-glycoprotein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.963
AHSG	ANXA2	ENSSSCP00000054117	ENSSSCP00000031749	Alpha-2-HS-glycoprotein.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.	0.654
AHSG	ANXA6	ENSSSCP00000054117	ENSSSCP00000018105	Alpha-2-HS-glycoprotein.	Annexin.	0.523
AHSG	MGP	ENSSSCP00000054117	ENSSSCP00000065033	Alpha-2-HS-glycoprotein.	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	0.731
ALB	AHSG	ENSSSCP00000053712	ENSSSCP00000054117	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Alpha-2-HS-glycoprotein.	0.963
ALB	AMELY	ENSSSCP00000053712	ENSSSCP00000072463	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.	0.411
ALB	ANXA11	ENSSSCP00000053712	ENSSSCP00000030026	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.650
ALB	ANXA13	ENSSSCP00000053712	ENSSSCP00000037349	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.623
ALB	ANXA2	ENSSSCP00000053712	ENSSSCP00000031749	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.	0.504
ALB	ANXA5	ENSSSCP00000053712	ENSSSCP00000009706	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.749
ALB	ANXA6	ENSSSCP00000053712	ENSSSCP00000018105	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.636
ALB	ANXA7	ENSSSCP00000053712	ENSSSCP00000022621	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Annexin.	0.634