STRINGSTRING
IFNB1 IFNB1 TNFSF11 TNFSF11 CTSC CTSC COL1A2 COL1A2 LCP2 LCP2 GRB2 GRB2 FSHR FSHR NFATC3 NFATC3 DVL3 DVL3 CTNNB1 CTNNB1 STAT1 STAT1 COL3A1 COL3A1 TGFB2 TGFB2 TNFRSF1A TNFRSF1A NCF2 NCF2 LCK LCK PIK3CB PIK3CB IFNGR2 IFNGR2 COL5A2 COL5A2 FOSL1 FOSL1 NGF NGF FZD4 FZD4 COL9A1 COL9A1 MEPE MEPE COL1A1 COL1A1 IFNAR1 IFNAR1 RUNX2 RUNX2 MAPK13 MAPK13 SPARC SPARC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNB1Interferon-beta-1. (186 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
NFATC3Nuclear factor of activated T cells 3. (1149 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
CTNNB1Catenin beta 1. (808 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
NCF2Neutrophil cytosolic factor 2. (643 aa)
LCKTyrosine-protein kinase. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
IFNGR2Interferon gamma receptor 2 isoform 1. (369 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (385 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
COL9A1Collagen type IX alpha 1 chain. (922 aa)
MEPEMatrix extracellular phosphoglycoprotein. (554 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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