18 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	STAT2	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	DDX18	RNA helicase. (786 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	MX1	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
	DDX39B	Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (467 aa)
	IFNAR2	Uncharacterized protein. (574 aa)
	STAT1	Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1573 aa)
	DDX55	RNA helicase. (600 aa)
	DDX31	RNA helicase. (816 aa)
	IFITM3	Uncharacterized protein. (206 aa)
	IRF9	IRF tryptophan pentad repeat domain-containing protein. (418 aa)
	IFNAR1	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)
	GATA2	GATA binding protein 2. (502 aa)
	IRF7	Interferon regulatory factor 7. (481 aa)
	DDX10	RNA helicase. (877 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX10	DDX18	ENSSSCP00000015935	ENSSSCP00000019922	RNA helicase.	RNA helicase.	0.992
DDX10	DDX31	ENSSSCP00000015935	ENSSSCP00000053770	RNA helicase.	RNA helicase.	0.885
DDX10	DDX55	ENSSSCP00000015935	ENSSSCP00000045699	RNA helicase.	RNA helicase.	0.679
DDX18	DDX10	ENSSSCP00000019922	ENSSSCP00000015935	RNA helicase.	RNA helicase.	0.992
DDX18	DDX31	ENSSSCP00000019922	ENSSSCP00000053770	RNA helicase.	RNA helicase.	0.864
DDX18	DDX55	ENSSSCP00000019922	ENSSSCP00000045699	RNA helicase.	RNA helicase.	0.894
DDX31	DDX10	ENSSSCP00000053770	ENSSSCP00000015935	RNA helicase.	RNA helicase.	0.885
DDX31	DDX18	ENSSSCP00000053770	ENSSSCP00000019922	RNA helicase.	RNA helicase.	0.864
DDX31	DDX55	ENSSSCP00000053770	ENSSSCP00000045699	RNA helicase.	RNA helicase.	0.712
DDX55	DDX10	ENSSSCP00000045699	ENSSSCP00000015935	RNA helicase.	RNA helicase.	0.679
DDX55	DDX18	ENSSSCP00000045699	ENSSSCP00000019922	RNA helicase.	RNA helicase.	0.894
DDX55	DDX31	ENSSSCP00000045699	ENSSSCP00000053770	RNA helicase.	RNA helicase.	0.712
IFITM3	IFNAR1	ENSSSCP00000060193	ENSSSCP00000067427	Uncharacterized protein.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.473
IFITM3	IRF7	ENSSSCP00000060193	ENSSSCP00000013664	Uncharacterized protein.	Interferon regulatory factor 7.	0.610
IFITM3	IRF9	ENSSSCP00000060193	ENSSSCP00000061619	Uncharacterized protein.	IRF tryptophan pentad repeat domain-containing protein.	0.489
IFITM3	MX1	ENSSSCP00000060193	ENSSSCP00000029166	Uncharacterized protein.	Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.	0.886
IFITM3	STAT1	ENSSSCP00000060193	ENSSSCP00000033087	Uncharacterized protein.	Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...]	0.514
IFITM3	STAT2	ENSSSCP00000060193	ENSSSCP00000069374	Uncharacterized protein.	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	0.404
IFITM3	STAT4	ENSSSCP00000060193	ENSSSCP00000020218	Uncharacterized protein.	Signal transducer and activator of transcription.	0.400
IFITM3	TLR3	ENSSSCP00000060193	ENSSSCP00000016745	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.659