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SMG7 SMG7 PTBP2 PTBP2 SMG1 SMG1 SRSF1 SRSF1 SPAG11B SPAG11B UPF2 UPF2 ATRN ATRN TSPAN7 TSPAN7 DAZAP1 DAZAP1 RBM5 RBM5 YBX3 YBX3 SYCP3 SYCP3 AKAP4 AKAP4 SRSF5 SRSF5 UPF1 UPF1 ALKBH5 ALKBH5 WTAP WTAP SMG5 SMG5 METTL14 METTL14 EXO1 EXO1 SOHLH1 SOHLH1 SPEF2 SPEF2 CDK11B CDK11B NASP NASP SPAG6 SPAG6 DAZL DAZL ACRBP ACRBP EHMT2 EHMT2 VIRMA VIRMA LHCGR LHCGR CREM CREM AR AR INCENP INCENP SPATA3 SPATA3 SMG6 SMG6 TDRD6 TDRD6 FSHR FSHR SPATA19 SPATA19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMG7SMG7 nonsense mediated mRNA decay factor. (1170 aa)
PTBP2Polypyrimidine tract binding protein 2. (506 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3646 aa)
SRSF1Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] (253 aa)
SPAG11BUncharacterized protein. (111 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1270 aa)
ATRNAttractin. (1416 aa)
TSPAN7Tetraspanin. (249 aa)
DAZAP1DAZ associated protein 1. (417 aa)
RBM5RNA binding motif protein 5. (893 aa)
YBX3Y-box binding protein 3. (380 aa)
SYCP3Synaptonemal complex protein 3. (236 aa)
AKAP4A-kinase anchoring protein 4. (863 aa)
SRSF5Serine and arginine rich splicing factor 5. (271 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
WTAPUncharacterized protein. (649 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
EXO1Exonuclease 1. (836 aa)
SOHLH1BHLH domain-containing protein. (285 aa)
SPEF2Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein- mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity). (2164 aa)
CDK11BProtein kinase domain-containing protein. (871 aa)
NASPNuclear autoantigenic sperm protein. (810 aa)
SPAG6Uncharacterized protein. (537 aa)
DAZLDeleted in azoospermia-like protein. (295 aa)
ACRBPAcrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (539 aa)
EHMT2Uncharacterized protein. (1233 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa)
CREMcAMP responsive element modulator. (360 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa)
INCENPInner centromere protein. (848 aa)
SPATA3Uncharacterized protein. (490 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1412 aa)
TDRD6Tudor domain containing 6. (2113 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
SPATA19Spermatogenesis-associated protein 19, mitochondrial. (154 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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