(16 nodes) (2020) Combining Kidney Organoids and Genome Editing Technologies for a Better Understanding of Physiopathological Mechanisms of Renal Diseases: State of the Art. network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SIX1	Six homeobox 1. (284 aa)
	BMP7	Bone morphogenetic protein 7. (650 aa)
	IFT140	Intraflagellar transport 140. (1477 aa)
	SIX2	SIX homeobox 2. (296 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (378 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	PAX2	Paired box 2. (416 aa)
	NPHS1	NPHS1 adhesion molecule, nephrin. (1239 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (668 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	CDH1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa)
	FGF9	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	ENSSSCP00000005423	ENSSSCP00000007993	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.842
BMP4	CDH1	ENSSSCP00000005423	ENSSSCP00000058117	Bone morphogenetic protein 4.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.470
BMP4	FGF2	ENSSSCP00000005423	ENSSSCP00000055271	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.875
BMP4	FGF9	ENSSSCP00000005423	ENSSSCP00000060438	Bone morphogenetic protein 4.	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	0.684
BMP4	GATA3	ENSSSCP00000005423	ENSSSCP00000041348	Bone morphogenetic protein 4.	Trans-acting T-cell-specific transcription factor GATA-3.	0.425
BMP4	PAX2	ENSSSCP00000005423	ENSSSCP00000031239	Bone morphogenetic protein 4.	Paired box 2.	0.554
BMP4	WNT4	ENSSSCP00000005423	ENSSSCP00000003822	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.484
BMP7	BMP4	ENSSSCP00000007993	ENSSSCP00000005423	Bone morphogenetic protein 7.	Bone morphogenetic protein 4.	0.842
BMP7	CDH1	ENSSSCP00000007993	ENSSSCP00000058117	Bone morphogenetic protein 7.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.483
BMP7	FGF2	ENSSSCP00000007993	ENSSSCP00000055271	Bone morphogenetic protein 7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.647
BMP7	FGF9	ENSSSCP00000007993	ENSSSCP00000060438	Bone morphogenetic protein 7.	Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity).	0.601
BMP7	PAX2	ENSSSCP00000007993	ENSSSCP00000031239	Bone morphogenetic protein 7.	Paired box 2.	0.559
BMP7	SIX2	ENSSSCP00000007993	ENSSSCP00000009014	Bone morphogenetic protein 7.	SIX homeobox 2.	0.445
BMP7	WNT4	ENSSSCP00000007993	ENSSSCP00000003822	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.453
BMP7	WNT9B	ENSSSCP00000007993	ENSSSCP00000056613	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.583
CDC42	CDH1	ENSSSCP00000029815	ENSSSCP00000058117	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.754
CDH1	BMP4	ENSSSCP00000058117	ENSSSCP00000005423	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Bone morphogenetic protein 4.	0.470
CDH1	BMP7	ENSSSCP00000058117	ENSSSCP00000007993	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Bone morphogenetic protein 7.	0.483
CDH1	CDC42	ENSSSCP00000058117	ENSSSCP00000029815	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.754
CDH1	FGF2	ENSSSCP00000058117	ENSSSCP00000055271	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.604