STRINGSTRING
COL8A2 COL8A2 IRX1 IRX1 THBS3 THBS3 ITGB2 ITGB2 MMP16 MMP16 INS INS CD163 CD163 DIO2 DIO2 COL4A5 COL4A5 ACSS2 ACSS2 COL6A5 COL6A5 LEP LEP ATF4 ATF4 ENTPD5 ENTPD5 C1QA C1QA COL11A2 COL11A2 MYH8 MYH8 THBS2 THBS2 LOC100517145 LOC100517145 C1QB C1QB SDS SDS COL14A1 COL14A1 COL6A1 COL6A1 COL1A1 COL1A1 DIRAS3 DIRAS3 CCN1 CCN1 TIMP2 TIMP2 DEPTOR DEPTOR MYO6 MYO6 TRIB1 TRIB1 LDLR LDLR RUNX2 RUNX2 COL8A1 COL8A1 COL6A6 COL6A6 RXRA RXRA ME1 ME1 ABCC3 ABCC3 COL11A1 COL11A1 COL21A1 COL21A1 NPC1 NPC1 BMP5 BMP5 CCN2 CCN2 CHAC1 CHAC1 COL2A1 COL2A1 ACTB ACTB TGFB2 TGFB2 SREBF1 SREBF1 C1QC C1QC HOXA10 HOXA10 COL16A1 COL16A1 HRH1 HRH1 COL3A1 COL3A1 ANGPTL1 ANGPTL1 STARD4 STARD4 GRB10 GRB10 TNFAIP3 TNFAIP3 TGFB3 TGFB3 TGFB1 TGFB1 AGT AGT COL6A3 COL6A3 PNPLA3 PNPLA3 GP6 GP6 HOXC10 HOXC10 COL6A2 COL6A2 IL6 IL6 PPP1R15B PPP1R15B HOXA9 HOXA9 ILK ILK THBS4 THBS4 TNFAIP6 TNFAIP6 CD68 CD68 ACLY ACLY STAT3 STAT3 NPC1L1 NPC1L1 C4BPA C4BPA IL10 IL10 ASNS ASNS COL1A2 COL1A2 IL10RA IL10RA ANGPTL5 ANGPTL5 CDO1 CDO1 C3 C3 TIMP1 TIMP1 VEGFD VEGFD EPHX1 EPHX1 TCF7L2 TCF7L2 PPP1R3C PPP1R3C BMP7 BMP7 COL5A1 COL5A1 ANGPTL2 ANGPTL2 SLC51B SLC51B THBS1 THBS1 COL12A1 COL12A1 ZNF521 ZNF521 MTOR MTOR ATF5 ATF5 CEBPA CEBPA FGF21 FGF21 PPARA PPARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL8A2Collagen type VIII alpha 2 chain. (707 aa)
IRX1Iroquois homeobox 1. (478 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (903 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
CD163Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1113 aa)
DIO2Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
COL6A5Collagen type VI alpha 5 chain. (2337 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
ATF4Activating transcription factor 4. (329 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (483 aa)
C1QAComplement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (266 aa)
COL11A2Collagen type XI alpha 2 chain. (1796 aa)
MYH8Myosin-4; Muscle contraction. (1940 aa)
THBS2Thrombospondin 2. (1223 aa)
LOC100517145Uncharacterized protein. (1670 aa)
C1QBComplement C1q B chain. (295 aa)
SDSSerine dehydratase. (402 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
DIRAS3GTP-binding RAS-like protein 3. (228 aa)
CCN1Cellular communication network factor 1. (382 aa)
TIMP2Uncharacterized protein. (257 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform 1. (409 aa)
MYO6Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). [...] (1285 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
COL8A1Collagen type VIII alpha 1 chain. (759 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
RXRARetinoid X receptor alpha. (701 aa)
ME1NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)
ABCC3ATP binding cassette subfamily C member 3. (1527 aa)
COL11A1Collagen type XI alpha 1 chain. (1816 aa)
COL21A1Collagen type XXI alpha 1 chain. (957 aa)
NPC1NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular traf [...] (1276 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CCN2CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
SREBF1Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). (1151 aa)
C1QCComplement C1q subcomponent subunit C isoform 1. (245 aa)
HOXA10Homeobox protein Hox-A10. (411 aa)
COL16A1Collagen alpha-1(XVI) chain isoform X2. (1624 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (506 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
ANGPTL1Angiopoietin-related protein 1 isoform X1. (502 aa)
STARD4StAR related lipid transfer domain containing 4. (213 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
COL6A3Collagen type VI alpha 3 chain. (2911 aa)
PNPLA3Patatin like phospholipase domain containing 3. (441 aa)
GP6Ig-like domain-containing protein. (319 aa)
HOXC10Homeobox C10. (342 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (709 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
ILKIntegrin linked kinase. (479 aa)
THBS4Thrombospondin 4. (976 aa)
TNFAIP6Uncharacterized protein. (277 aa)
CD68Macrosialin isoform A. (318 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
NPC1L1NPC1-like intracellular cholesterol transporter 1 isoform 2. (1332 aa)
C4BPAApolipoprotein R; May be a lipoprotein-borne regulator of either the coagulation or the complement cascades. (613 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (545 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
ANGPTL5Angiopoietin-related protein 5. (388 aa)
CDO1Cysteine dioxygenase. (200 aa)
C3Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (1661 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
VEGFDVascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
EPHX1Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family. (452 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
ANGPTL2Angiopoietin-related protein 2. (493 aa)
SLC51BOrganic solute transporter subunit beta. (131 aa)
THBS1Uncharacterized protein. (1170 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
ZNF521Zinc finger protein 521. (1310 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
ATF5Activating transcription factor 5. (282 aa)
CEBPACCAAT/enhancer-binding protein alpha isoform c. (354 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPARAUncharacterized protein. (469 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.