STRINGSTRING
DCN DCN LUM LUM COL12A1 COL12A1 THBS1 THBS1 COL5A1 COL5A1 BGLAP BGLAP POSTN POSTN SERPIND1 SERPIND1 SPP2 SPP2 VTN VTN BGN BGN PGLYRP1 PGLYRP1 ANXA2 ANXA2 S100A12 S100A12 COL3A1 COL3A1 APOA1 APOA1 CHAD CHAD CLEC3B CLEC3B SERPINF1 SERPINF1 ALB ALB AHSG AHSG COL11A2 COL11A2 HBB HBB SERPINC1 SERPINC1 SPARC SPARC NUCB1 NUCB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
LUMLumican. (341 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
THBS1Uncharacterized protein. (1170 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
POSTNPeriostin. (836 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (517 aa)
SPP2Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover; Belongs to the SPP2 family. (208 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
PGLYRP120 kDa neutrophil cationic protein. (222 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
S100A12Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
CHADChondroadherin. (359 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (433 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
AHSGAlpha-2-HS-glycoprotein. (394 aa)
COL11A2Collagen type XI alpha 2 chain. (1796 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (239 aa)
SERPINC1SERPIN domain-containing protein; Belongs to the serpin family. (431 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
NUCB1Nucleobindin 1. (458 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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