STRINGSTRING
COL14A1 COL14A1 IGFBP2 IGFBP2 ACTG2 ACTG2 RTP4 RTP4 ACTA2 ACTA2 TAGLN TAGLN REN REN TPM2 TPM2 IL13 IL13 SERPINE1 SERPINE1 CYGB CYGB COL1A2 COL1A2 MMP1 MMP1 PDGFRB PDGFRB PI16 PI16 TIMP1 TIMP1 THBS1 THBS1 COL5A1 COL5A1 POSTN POSTN IL6 IL6 COL13A1 COL13A1 LTBP2 LTBP2 DEPTOR DEPTOR COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
IGFBP2Insulin-like growth factor-binding protein 2; May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (316 aa)
ACTG2Actin gamma 2, smooth muscle. (417 aa)
RTP4Receptor-transporting protein 4. (550 aa)
ACTA2Actin alpha 2, smooth muscle. (386 aa)
TAGLNTransgelin; Belongs to the calponin family. (239 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (359 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
CYGBGLOBIN domain-containing protein; Belongs to the globin family. (410 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
MMP1Stromelysin-1 preproprotein. (477 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
PI16SCP domain-containing protein; Belongs to the CRISP family. (460 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
THBS1Uncharacterized protein. (1170 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
POSTNPeriostin. (836 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
COL13A1Collagen type XIII alpha 1 chain. (726 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform 1. (409 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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