STRINGSTRING
DGAT1 DGAT1 PLIN2 PLIN2 LPIN1 LPIN1 PDHX PDHX ANGPT1 ANGPT1 ETS1 ETS1 PLIN5 PLIN5 RXRG RXRG ACSS2 ACSS2 AQP7 AQP7 CROT CROT HIF1AN HIF1AN NCOA1 NCOA1 MLXIPL MLXIPL ACSS1 ACSS1 DIO2 DIO2 INS INS CPT1B CPT1B SETD7 SETD7 NCOA2 NCOA2 TBP TBP FABP5 FABP5 ACTB ACTB MGLL MGLL FOXA2 FOXA2 PPARGC1A PPARGC1A TCF7 TCF7 PIK3R1 PIK3R1 PRKAA1 PRKAA1 AOX1 AOX1 ACSM5 ACSM5 STAT6 STAT6 SLC2A4 SLC2A4 ATF3 ATF3 PPARG PPARG TCF7L2 TCF7L2 NCOA6 NCOA6 E2F1 E2F1 CREG1 CREG1 ACAA2 ACAA2 NFKBIA NFKBIA PPARD PPARD PPARA PPARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DGAT1Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (665 aa)
PLIN2Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family. (459 aa)
LPIN1Lipin 1. (957 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (498 aa)
ANGPT1Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa)
ETS1ETS proto-oncogene 1, transcription factor. (621 aa)
PLIN5Perilipin 5. (736 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (336 aa)
CROTCarn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (361 aa)
NCOA1Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa)
MLXIPLMLX interacting protein like. (970 aa)
ACSS1Acetyl-coenzyme A synthetase. (703 aa)
DIO2Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform. (807 aa)
SETD7SET domain containing 7, histone lysine methyltransferase. (539 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
TBPUncharacterized protein. (153 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (235 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
MGLLMonoglyceride lipase. (456 aa)
FOXA2Hepatocyte nuclear factor 3-beta isoform 1. (463 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
TCF7Transcription factor 7. (484 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
AOX1Uncharacterized protein. (1338 aa)
ACSM5Acyl-coenzyme A synthetase ACSM5, mitochondrial isoform 1. (579 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3 isoform X1. (250 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
NCOA6Nuclear receptor coactivator 6. (2061 aa)
E2F1E2F transcription factor 1. (435 aa)
CREG1Cellular repressor of E1A stimulated genes 1; Belongs to the CREG family. (222 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
PPARAUncharacterized protein. (469 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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