24 items (Sus scrofa) - STRING interaction network

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
	PPARA	Uncharacterized protein. (469 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
	VIRMA	Vir like m6A methyltransferase associated. (1812 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
	PTEN	Uncharacterized protein. (576 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	MPO	Myeloperoxidase. (731 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (652 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
	YAP1	Yes associated protein 1. (432 aa)
	LIF	Leukemia inhibitory factor isoform X1. (202 aa)
	IL11	Interleukin 11. (199 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)
	WTAP	Uncharacterized protein. (649 aa)
	HNRNPA2B1	Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
	SRSF2	Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...] (221 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	METTL14	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
	FTO	FTO_NTD domain-containing protein. (509 aa)
	YTHDF3	YTH domain-containing family protein 3 isoform b. (588 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)
	YTHDC1	YTH domain containing 1. (743 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (600 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH5	FTO	ENSSSCP00000038766	ENSSSCP00000047110	AlkB homolog 5, RNA demethylase.	FTO_NTD domain-containing protein.	0.979
ALKBH5	HNRNPA2B1	ENSSSCP00000038766	ENSSSCP00000040227	AlkB homolog 5, RNA demethylase.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.639
ALKBH5	METTL14	ENSSSCP00000038766	ENSSSCP00000046701	AlkB homolog 5, RNA demethylase.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.953
ALKBH5	VIRMA	ENSSSCP00000038766	ENSSSCP00000006511	AlkB homolog 5, RNA demethylase.	Vir like m6A methyltransferase associated.	0.828
ALKBH5	WTAP	ENSSSCP00000038766	ENSSSCP00000039764	AlkB homolog 5, RNA demethylase.	Uncharacterized protein.	0.975
ALKBH5	YTHDC1	ENSSSCP00000038766	ENSSSCP00000049284	AlkB homolog 5, RNA demethylase.	YTH domain containing 1.	0.874
ALKBH5	YTHDC2	ENSSSCP00000038766	ENSSSCP00000048904	AlkB homolog 5, RNA demethylase.	YTH domain containing 2.	0.858
ALKBH5	YTHDF1	ENSSSCP00000038766	ENSSSCP00000031181	AlkB homolog 5, RNA demethylase.	YTH N6-methyladenosine RNA binding protein 1.	0.917
ALKBH5	YTHDF2	ENSSSCP00000038766	ENSSSCP00000065604	AlkB homolog 5, RNA demethylase.	YTH N6-methyladenosine RNA binding protein 2.	0.913
ALKBH5	YTHDF3	ENSSSCP00000038766	ENSSSCP00000048507	AlkB homolog 5, RNA demethylase.	YTH domain-containing family protein 3 isoform b.	0.890
EPO	IGF1	ENSSSCP00000008194	ENSSSCP00000000915	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.583
EPO	IL6	ENSSSCP00000008194	ENSSSCP00000023819	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.694
EPO	INS	ENSSSCP00000008194	ENSSSCP00000044635	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.748
FTO	ALKBH5	ENSSSCP00000047110	ENSSSCP00000038766	FTO_NTD domain-containing protein.	AlkB homolog 5, RNA demethylase.	0.979
FTO	HNRNPA2B1	ENSSSCP00000047110	ENSSSCP00000040227	FTO_NTD domain-containing protein.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.559
FTO	INS	ENSSSCP00000047110	ENSSSCP00000044635	FTO_NTD domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.417
FTO	METTL14	ENSSSCP00000047110	ENSSSCP00000046701	FTO_NTD domain-containing protein.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.905
FTO	VIRMA	ENSSSCP00000047110	ENSSSCP00000006511	FTO_NTD domain-containing protein.	Vir like m6A methyltransferase associated.	0.791
FTO	WTAP	ENSSSCP00000047110	ENSSSCP00000039764	FTO_NTD domain-containing protein.	Uncharacterized protein.	0.912
FTO	YTHDC1	ENSSSCP00000047110	ENSSSCP00000049284	FTO_NTD domain-containing protein.	YTH domain containing 1.	0.830