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CREBBP CREBBP EPO EPO RORA RORA EDNRA EDNRA SEC24B SEC24B CYSLTR2 CYSLTR2 TBX5 TBX5 ADORA2A ADORA2A SIRT1 SIRT1 CYP17A1 CYP17A1 ADAMTS9 ADAMTS9 VEGFB VEGFB ANGPTL4 ANGPTL4 PRCP PRCP ADAM9 ADAM9 EPHA1 EPHA1 ANKH ANKH TMPRSS6 TMPRSS6 I3LER3_PIG I3LER3_PIG PRKAA1 PRKAA1 PIK3C2A PIK3C2A ATP12A ATP12A P4HA3 P4HA3 WNT7B WNT7B P4HA1 P4HA1 LDHA LDHA PKLR PKLR UBE2D1 UBE2D1 MYLK MYLK BRINP3 BRINP3 PAFAH1B2 PAFAH1B2 SOD2 SOD2 CIC CIC ENO1 ENO1 BHLHE41 BHLHE41 COL4A4 COL4A4 VASN VASN HIF1AN HIF1AN P4HA2 P4HA2 SLC29A1 SLC29A1 LIPE LIPE SPINT1 SPINT1 ALDOA ALDOA SENP1 SENP1 KAT6A KAT6A ZNF532 ZNF532 THRB THRB SFTPD SFTPD TXNRD2 TXNRD2 SIRT2 SIRT2 ANGPT1 ANGPT1 VAV3 VAV3 HBB HBB TGFBR3 TGFBR3 RYR2 RYR2 MYO5B MYO5B REST REST ACAA2 ACAA2 ANGPTL3 ANGPTL3 PINK1 PINK1 PAFAH1B3 PAFAH1B3 ARG2 ARG2 STRA6 STRA6 ADAM17 ADAM17 PPARA PPARA CIAO3 CIAO3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREBBPCREB-binding protein isoform a. (2440 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa)
RORARAR related orphan receptor A. (530 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1258 aa)
CYSLTR2Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). (361 aa)
TBX5T-box transcription factor 5. (535 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (2020 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa)
ANGPTL4Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa)
PRCPProlylcarboxypeptidase. (511 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
EPHA1Ephrin type-A receptor 1. (982 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (494 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (812 aa)
I3LER3_PIGUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (217 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1044 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha-3 isoform 1. (544 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha-1 isoform 1. (534 aa)
LDHAL-lactate dehydrogenase A chain. (443 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
MYLKMyosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). (1981 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (766 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (485 aa)
CICCapicua transcriptional repressor. (2520 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (482 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
VASNVasorin isoform X2. (677 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (361 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (555 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (548 aa)
LIPEHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (531 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (532 aa)
SENP1SUMO specific peptidase 1. (677 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (829 aa)
ZNF532Zinc finger protein 532. (1313 aa)
THRBThyroid hormone receptor beta isoform X2. (476 aa)
SFTPDPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa)
TXNRD2Uncharacterized protein. (606 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
ANGPT1Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (239 aa)
TGFBR3Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa)
RYR2Ryanodine receptor 2. (4966 aa)
MYO5BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1845 aa)
RESTRE1 silencing transcription factor. (1108 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (461 aa)
PINK1PTEN induced kinase 1. (588 aa)
PAFAH1B3Platelet activating factor acetylhydrolase 1b catalytic subunit 3. (232 aa)
ARG2Arginase. (354 aa)
STRA6Stimulated by retinoic acid 6. (666 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membra [...] (822 aa)
PPARAUncharacterized protein. (469 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (633 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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