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CREBBP | CREB-binding protein isoform a. (2440 aa) | ||||
EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa) | ||||
RORA | RAR related orphan receptor A. (530 aa) | ||||
EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) | ||||
SEC24B | SEC24 homolog B, COPII coat complex component. (1258 aa) | ||||
CYSLTR2 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). (361 aa) | ||||
TBX5 | T-box transcription factor 5. (535 aa) | ||||
ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa) | ||||
SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) | ||||
CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa) | ||||
ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif 9. (2020 aa) | ||||
VEGFB | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa) | ||||
ANGPTL4 | Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa) | ||||
PRCP | Prolylcarboxypeptidase. (511 aa) | ||||
ADAM9 | Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa) | ||||
EPHA1 | Ephrin type-A receptor 1. (982 aa) | ||||
ANKH | ANKH inorganic pyrophosphate transport regulator. (494 aa) | ||||
TMPRSS6 | Transmembrane serine protease 6; Belongs to the peptidase S1 family. (812 aa) | ||||
I3LER3_PIG | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (217 aa) | ||||
PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) | ||||
PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa) | ||||
ATP12A | Sodium/potassium-transporting ATPase subunit alpha. (1044 aa) | ||||
P4HA3 | Prolyl 4-hydroxylase subunit alpha-3 isoform 1. (544 aa) | ||||
WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) | ||||
P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 isoform 1. (534 aa) | ||||
LDHA | L-lactate dehydrogenase A chain. (443 aa) | ||||
PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (565 aa) | ||||
UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) | ||||
MYLK | Myosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). (1981 aa) | ||||
BRINP3 | BMP/retinoic acid inducible neural specific 3. (766 aa) | ||||
PAFAH1B2 | Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa) | ||||
SOD2 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (485 aa) | ||||
CIC | Capicua transcriptional repressor. (2520 aa) | ||||
ENO1 | Alpha-enolase isoform X1. (434 aa) | ||||
BHLHE41 | Class E basic helix-loop-helix protein 41. (482 aa) | ||||
COL4A4 | Collagen type IV alpha 4 chain. (1691 aa) | ||||
VASN | Vasorin isoform X2. (677 aa) | ||||
HIF1AN | Hypoxia inducible factor 1 subunit alpha inhibitor. (361 aa) | ||||
P4HA2 | Prolyl 4-hydroxylase subunit alpha 2. (555 aa) | ||||
SLC29A1 | Solute carrier family 29 member 1 (Augustine blood group). (548 aa) | ||||
LIPE | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa) | ||||
SPINT1 | Serine peptidase inhibitor, Kunitz type 1. (531 aa) | ||||
ALDOA | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (532 aa) | ||||
SENP1 | SUMO specific peptidase 1. (677 aa) | ||||
KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (829 aa) | ||||
ZNF532 | Zinc finger protein 532. (1313 aa) | ||||
THRB | Thyroid hormone receptor beta isoform X2. (476 aa) | ||||
SFTPD | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa) | ||||
TXNRD2 | Uncharacterized protein. (606 aa) | ||||
SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa) | ||||
ANGPT1 | Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa) | ||||
VAV3 | Vav guanine nucleotide exchange factor 3. (874 aa) | ||||
HBB | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (239 aa) | ||||
TGFBR3 | Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa) | ||||
RYR2 | Ryanodine receptor 2. (4966 aa) | ||||
MYO5B | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1845 aa) | ||||
REST | RE1 silencing transcription factor. (1108 aa) | ||||
ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) | ||||
ANGPTL3 | Fibrinogen C-terminal domain-containing protein. (461 aa) | ||||
PINK1 | PTEN induced kinase 1. (588 aa) | ||||
PAFAH1B3 | Platelet activating factor acetylhydrolase 1b catalytic subunit 3. (232 aa) | ||||
ARG2 | Arginase. (354 aa) | ||||
STRA6 | Stimulated by retinoic acid 6. (666 aa) | ||||
ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membra [...] (822 aa) | ||||
PPARA | Uncharacterized protein. (469 aa) | ||||
CIAO3 | Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (633 aa) |