STRINGSTRING
PPARG PPARG PRPF19 PRPF19 MRPL16 MRPL16 CWC22 CWC22 FASN FASN YTHDF1 YTHDF1 FAF2 FAF2 CPSF6 CPSF6 LRP4 LRP4 ACSL1 ACSL1 METTL14 METTL14 YTHDC1 YTHDC1 IGFBP2 IGFBP2 RPL10A RPL10A NUDT3 NUDT3 YTHDF2 YTHDF2 LPIN1 LPIN1 FAF1 FAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
PRPF19Pre-mRNA-processing factor 19. (504 aa)
MRPL1639S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family. (251 aa)
CWC22CWC22 spliceosome associated protein homolog. (903 aa)
FASNUncharacterized protein. (1430 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
FAF2Fas associated factor family member 2. (445 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform 2. (588 aa)
LRP4LDL receptor related protein 4. (1918 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (771 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
YTHDC1YTH domain containing 1. (743 aa)
IGFBP2Insulin-like growth factor-binding protein 2; May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (316 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. (219 aa)
NUDT3Nudix hydrolase domain-containing protein. (291 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
LPIN1Lipin 1. (957 aa)
FAF1Fas associated factor 1. (657 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.