23 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CALML4	Uncharacterized protein. (154 aa)
	CALM3	Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
	CCL4	C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	ARRB2	Arrestin beta 2. (493 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
	PRKD3	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (891 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (700 aa)
	ADRA1A	Alpha-1A adrenergic receptor isoform 1. (466 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
	ARRB1	Arrestin beta 1. (607 aa)
	CCL24	SCY domain-containing protein. (183 aa)
	CCR2	C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	CX3CR1	CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa)
	CCL17	C-C motif chemokine. (102 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
	CALML5	Calmodulin like 5. (149 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	CCL22	C-C motif chemokine. (93 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
	CXCL11	C-X-C motif chemokine. (129 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSSSCP00000033134	ENSSSCP00000060730	Arrestin beta 1.	Arrestin beta 2.	0.923
ARRB1	CALML4	ENSSSCP00000033134	ENSSSCP00000071054	Arrestin beta 1.	Uncharacterized protein.	0.448
ARRB1	CALML5	ENSSSCP00000033134	ENSSSCP00000011880	Arrestin beta 1.	Calmodulin like 5.	0.448
ARRB1	CCR2	ENSSSCP00000033134	ENSSSCP00000024949	Arrestin beta 1.	C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family.	0.718
ARRB1	CX3CR1	ENSSSCP00000033134	ENSSSCP00000021160	Arrestin beta 1.	CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family.	0.692
ARRB1	CXCL12	ENSSSCP00000033134	ENSSSCP00000066937	Arrestin beta 1.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.574
ARRB1	PRKACA	ENSSSCP00000033134	ENSSSCP00000035101	Arrestin beta 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.603
ARRB1	PRKACB	ENSSSCP00000033134	ENSSSCP00000058922	Arrestin beta 1.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.603
ARRB2	ARRB1	ENSSSCP00000060730	ENSSSCP00000033134	Arrestin beta 2.	Arrestin beta 1.	0.923
ARRB2	CALML4	ENSSSCP00000060730	ENSSSCP00000071054	Arrestin beta 2.	Uncharacterized protein.	0.458
ARRB2	CALML5	ENSSSCP00000060730	ENSSSCP00000011880	Arrestin beta 2.	Calmodulin like 5.	0.458
ARRB2	CCR2	ENSSSCP00000060730	ENSSSCP00000024949	Arrestin beta 2.	C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family.	0.719
ARRB2	CX3CR1	ENSSSCP00000060730	ENSSSCP00000021160	Arrestin beta 2.	CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family.	0.692
ARRB2	CXCL12	ENSSSCP00000060730	ENSSSCP00000066937	Arrestin beta 2.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.586
ARRB2	PRKACA	ENSSSCP00000060730	ENSSSCP00000035101	Arrestin beta 2.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.610
ARRB2	PRKACB	ENSSSCP00000060730	ENSSSCP00000058922	Arrestin beta 2.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.610
CALM3	CALML4	ENSSSCP00000068530	ENSSSCP00000071054	Uncharacterized protein; Belongs to the calmodulin family.	Uncharacterized protein.	0.964
CALM3	CALML5	ENSSSCP00000068530	ENSSSCP00000011880	Uncharacterized protein; Belongs to the calmodulin family.	Calmodulin like 5.	0.963
CALM3	PRKACA	ENSSSCP00000068530	ENSSSCP00000035101	Uncharacterized protein; Belongs to the calmodulin family.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.978
CALM3	PRKACB	ENSSSCP00000068530	ENSSSCP00000058922	Uncharacterized protein; Belongs to the calmodulin family.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.978