33 items (Sus scrofa) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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textmining

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protein homology

Your Input:
	MYH7	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
	PGGT1B	Protein geranylgeranyltransferase type I subunit beta. (377 aa)
	PLPP3	acidPPc domain-containing protein. (369 aa)
	DMD	Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3679 aa)
	APOC3	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
	TBC1D8	TBC1 domain family member 8. (1143 aa)
	FMO3	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	PHACTR1	Phosphatase and actin regulator. (651 aa)
	STXBP5	Syntaxin binding protein 5. (1179 aa)
	AADAC	Arylacetamide deacetylase. (399 aa)
	CNN2	Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (396 aa)
	APOB	Apolipoprotein B-100. (4573 aa)
	PIGR	Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface (By similarity). (792 aa)
	ANGPTL8	Angiopoietin-like protein 8. (198 aa)
	STX8	Syntaxin 8. (301 aa)
	AGXT2	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
	LEF1	Lymphoid enhancer binding factor 1. (429 aa)
	FCAMR	Uncharacterized protein. (479 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
	LIPG	Lipase G, endothelial type. (501 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, prot [...] (1280 aa)
	LCAT	Phosphatidylcholine-sterol acyltransferase. (471 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (678 aa)
	CD36	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
	CXCL14	SCY domain-containing protein. (110 aa)
	MTTP	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (894 aa)
	ABCA1	Uncharacterized protein. (2261 aa)
	AQP9	Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
	ANGPTL3	Fibrinogen C-terminal domain-containing protein. (461 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2139 aa)
	VWF	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAC	APOB	ENSSSCP00000048673	ENSSSCP00000042786	Arylacetamide deacetylase.	Apolipoprotein B-100.	0.444
AADAC	FMO3	ENSSSCP00000048673	ENSSSCP00000055883	Arylacetamide deacetylase.	Dimethylaniline monooxygenase [N-oxide-forming].	0.443
AADAC	HECTD1	ENSSSCP00000048673	ENSSSCP00000002152	Arylacetamide deacetylase.	HECT domain E3 ubiquitin protein ligase 1.	0.402
AADAC	PGGT1B	ENSSSCP00000048673	ENSSSCP00000070240	Arylacetamide deacetylase.	Protein geranylgeranyltransferase type I subunit beta.	0.400
ABCA1	APOB	ENSSSCP00000005818	ENSSSCP00000042786	Uncharacterized protein.	Apolipoprotein B-100.	0.738
ABCA1	APOC3	ENSSSCP00000005818	ENSSSCP00000063050	Uncharacterized protein.	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...]	0.646
ABCA1	APOE	ENSSSCP00000005818	ENSSSCP00000003343	Uncharacterized protein.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.912
ABCA1	CD36	ENSSSCP00000005818	ENSSSCP00000016332	Uncharacterized protein.	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	0.577
ABCA1	LCAT	ENSSSCP00000005818	ENSSSCP00000024443	Uncharacterized protein.	Phosphatidylcholine-sterol acyltransferase.	0.723
ABCA1	MTTP	ENSSSCP00000005818	ENSSSCP00000009789	Uncharacterized protein.	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.	0.504
ABCA1	PCSK9	ENSSSCP00000005818	ENSSSCP00000023105	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 9.	0.505
ABCA1	SCAP	ENSSSCP00000005818	ENSSSCP00000026028	Uncharacterized protein.	Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, prot [...]	0.424
AGXT2	HECTD1	ENSSSCP00000034701	ENSSSCP00000002152	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	HECT domain E3 ubiquitin protein ligase 1.	0.453
AGXT2	PGGT1B	ENSSSCP00000034701	ENSSSCP00000070240	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Protein geranylgeranyltransferase type I subunit beta.	0.452
AGXT2	SCAP	ENSSSCP00000034701	ENSSSCP00000026028	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, prot [...]	0.449
ANGPTL3	ANGPTL8	ENSSSCP00000004131	ENSSSCP00000038848	Fibrinogen C-terminal domain-containing protein.	Angiopoietin-like protein 8.	0.991
ANGPTL3	APOB	ENSSSCP00000004131	ENSSSCP00000042786	Fibrinogen C-terminal domain-containing protein.	Apolipoprotein B-100.	0.650
ANGPTL3	APOC3	ENSSSCP00000004131	ENSSSCP00000063050	Fibrinogen C-terminal domain-containing protein.	Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...]	0.657
ANGPTL3	LIPG	ENSSSCP00000004131	ENSSSCP00000027699	Fibrinogen C-terminal domain-containing protein.	Lipase G, endothelial type.	0.590
ANGPTL3	MTTP	ENSSSCP00000004131	ENSSSCP00000009789	Fibrinogen C-terminal domain-containing protein.	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.	0.464