STRINGSTRING
SYNM SYNM PRELP PRELP CKB CKB DCN DCN LUM LUM CKMT1A CKMT1A ANXA9 ANXA9 UMOD UMOD ASPN ASPN FABP1 FABP1 ANXA5 ANXA5 SPP1 SPP1 POSTN POSTN VCL VCL INSR INSR LOX LOX FMOD FMOD MSTN MSTN FLNC FLNC SGCD SGCD ANXA6 ANXA6 GRB2 GRB2 ACE ACE CD4 CD4 SSPN SSPN SNTB2 SNTB2 ANXA7 ANXA7 ACE2 ACE2 BGN BGN ANXA11 ANXA11 MPO MPO CKMT2 CKMT2 AGRN AGRN DPT DPT FABP4 FABP4 FABP5 FABP5 CAVIN1 CAVIN1 ANXA13 ANXA13 TRPV2 TRPV2 AHNAK AHNAK SGK1 SGK1 FABP3 FABP3 TLN1 TLN1 DTNA DTNA HP HP MMP9 MMP9 TLN2 TLN2 MDH2 MDH2 CKM CKM PLG PLG LOC100515049 LOC100515049 UTRN UTRN AHNAK-2 AHNAK-2 ANXA8 ANXA8 TTN TTN FLNB FLNB GOT2 GOT2 DAG1 DAG1 CST3 CST3 PLEC PLEC ACAN ACAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYNMIF rod domain-containing protein; Belongs to the intermediate filament family. (339 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (403 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
LUMLumican. (341 aa)
CKMT1ACreatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (416 aa)
ANXA9Annexin. (360 aa)
UMODUromodulin. (642 aa)
ASPNAsporin. (370 aa)
FABP1Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (151 aa)
ANXA5Annexin. (321 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
POSTNPeriostin. (836 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
FLNCFilamin-C isoform X4. (2720 aa)
SGCDSarcoglycan delta. (290 aa)
ANXA6Annexin. (672 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
CD4CD4 molecule. (494 aa)
SSPNSarcospan. (243 aa)
SNTB2Syntrophin beta 2. (542 aa)
ANXA7Annexin. (485 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
ANXA11Annexin. (516 aa)
MPOMyeloperoxidase. (731 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (443 aa)
AGRNAgrin. (2108 aa)
DPTDermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation (By similarity). Accelerates collagen fibril formation, and stabilizes collagen fibrils against low- temperature dissociation. (201 aa)
FABP4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (235 aa)
CAVIN1Caveolae associated protein 1. (458 aa)
ANXA13Annexin. (357 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (854 aa)
AHNAKUncharacterized protein. (2177 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
FABP3Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. (133 aa)
TLN1Talin 1. (2558 aa)
DTNADystrobrevin. (725 aa)
HPHaptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (354 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
TLN2Talin 2. (2542 aa)
MDH2Malate dehydrogenase, mitochondrial. (395 aa)
CKMCreatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (380 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
LOC100515049Angiotensin-converting enzyme. (771 aa)
UTRNUncharacterized protein. (3433 aa)
AHNAK-2PDZ domain-containing protein. (227 aa)
ANXA8Annexin. (354 aa)
TTNUncharacterized protein. (563 aa)
FLNBFilamin B. (2633 aa)
GOT2Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
CST3Cystatin C; Belongs to the cystatin family. (146 aa)
PLECPlectin. (5422 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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