STRINGSTRING
A2M A2M GPX6 GPX6 GPX5 GPX5 GPX2 GPX2 NPPA NPPA ACTC1 ACTC1 PTGES2 PTGES2 TRAF2 TRAF2 VIRMA VIRMA RBM15 RBM15 PLAT PLAT MAVS MAVS PTGIS PTGIS ACTA2 ACTA2 RBM15B RBM15B P2RY12 P2RY12 TLR8 TLR8 CFD CFD CD36 CD36 TLR3 TLR3 TBXAS1 TBXAS1 ACE ACE PLD2 PLD2 TLR6 TLR6 P2RY11 P2RY11 TLR1 TLR1 PDGFC PDGFC TLR10 TLR10 TNNT2 TNNT2 GPX8 GPX8 PTGER2 PTGER2 MASP2 MASP2 ACE2 ACE2 IRF3 IRF3 TRAF5 TRAF5 CFB CFB AGTR1 AGTR1 YY1 YY1 PLD1 PLD1 GPX7 GPX7 PLCB4 PLCB4 PRDX2 PRDX2 WTAP WTAP GPX1 GPX1 TRAF3 TRAF3 GPX3 GPX3 REN REN PRPS2 PRPS2 METTL14 METTL14 SERPINE2 SERPINE2 P2RY6 P2RY6 C1QA C1QA PLA2G4A PLA2G4A NOS2 NOS2 THBD THBD TLR4 TLR4 MASP1 MASP1 ANPEP ANPEP TLR2 TLR2 LOC100515049 LOC100515049 PLG PLG APLN APLN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A2MAlpha-2-macroglobulin. (1504 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
GPX5Epididymal secretory glutathione peroxidase; May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. (219 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
PTGES2Prostaglandin E synthase 2. (372 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
RBM15RNA binding motif protein 15. (1006 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
ACTA2Actin alpha 2, smooth muscle. (386 aa)
RBM15BRNA binding motif protein 15B. (854 aa)
P2RY12Purinergic receptor P2Y12. (339 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1117 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
TBXAS1Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
PLD2Phospholipase. (933 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
P2RY11PPAN-P2RY11 protein isoform 1; Belongs to the G-protein coupled receptor 1 family. (377 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
TLR10TIR domain-containing protein; Belongs to the Toll-like receptor family. (810 aa)
TNNT2Uncharacterized protein. (295 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MASP2Uncharacterized protein; Belongs to the peptidase S1 family. (823 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
CFBComplement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family. (851 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa)
YY1YY1 transcription factor. (438 aa)
PLD1Phospholipase. (1074 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (317 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PRDX2Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (237 aa)
WTAPUncharacterized protein. (649 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
PRPS2TIR domain-containing protein. (1337 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
P2RY6Pyrimidinergic receptor P2Y6. (515 aa)
C1QAComplement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. (266 aa)
PLA2G4APhospholipase A2. (758 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1195 aa)
THBDUncharacterized protein. (529 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
MASP1Mannan-binding lectin serine protease 1 isoform 2; Belongs to the peptidase S1 family. (728 aa)
ANPEPAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met [...] (1017 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC100515049Angiotensin-converting enzyme. (771 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
APLNApelin. (77 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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