STRINGSTRING
METTL3 METTL3 SOD1 SOD1 PRM2 PRM2 TEKT2 TEKT2 SIRT1 SIRT1 ACO2 ACO2 PTEN PTEN AIFM1 AIFM1 FSHB FSHB HAT1 HAT1 HOXA3 HOXA3 LOC100521680 LOC100521680 HBB HBB YTHDF2 YTHDF2 DKK3 DKK3 ACO1 ACO1 MGMT MGMT HOXB5 HOXB5 CATSPER2 CATSPER2 HIST1H3E HIST1H3E CLU CLU CASP3 CASP3 TEKT1 TEKT1 FTO FTO METTL14 METTL14 CLUL1 CLUL1 UBE3A UBE3A RPL31 RPL31 ALKBH5 ALKBH5 A0A286ZTM7_PIG A0A286ZTM7_PIG BCL2L1 BCL2L1 HDAC1 HDAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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METTL3N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (580 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa)
PRM2Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. (93 aa)
TEKT2Tektin-2 isoform X1. (430 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
ACO2Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. (780 aa)
PTENUncharacterized protein. (576 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (418 aa)
HOXA3Homeobox protein Hox-A3 isoform a. (443 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (239 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (433 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (265 aa)
HOXB5Homeobox protein Hox-B5. (269 aa)
CATSPER2Cation channel sperm associated 2. (538 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
TEKT1Tektin 1. (418 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
CLUL1Clusterin; Belongs to the clusterin family. (469 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
RPL3160S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family. (129 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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