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PTGS1 | Prostaglandin G/H synthase 1 isoform 1. (600 aa) | ||||
GPX6 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa) | ||||
GPX5 | Epididymal secretory glutathione peroxidase; May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. (219 aa) | ||||
GPX2 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa) | ||||
FBLN5 | Fibulin-5 isoform X2. (461 aa) | ||||
APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) | ||||
FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) | ||||
FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa) | ||||
PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) | ||||
SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa) | ||||
COL4A2 | Collagen type IV alpha 2 chain. (1712 aa) | ||||
SERPIND1 | Serpin family D member 1; Belongs to the serpin family. (517 aa) | ||||
OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa) | ||||
ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) | ||||
PLIN4 | Perilipin 4. (1655 aa) | ||||
UCP2 | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). (308 aa) | ||||
MMP8 | Matrix metallopeptidase 8. (468 aa) | ||||
COL1A2 | Fibrillar collagen NC1 domain-containing protein. (1135 aa) | ||||
MSTN | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa) | ||||
ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa) | ||||
SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa) | ||||
PXDN | Peroxidasin. (1529 aa) | ||||
COL6A2 | Collagen type VI alpha 2 chain. (943 aa) | ||||
GPX8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa) | ||||
COL6A3 | Collagen type VI alpha 3 chain. (2911 aa) | ||||
AMBP | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. (364 aa) | ||||
HMMR | Hyaluronan mediated motility receptor. (722 aa) | ||||
PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) | ||||
APOC2 | Uncharacterized protein. (198 aa) | ||||
SREBF1 | Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). (1151 aa) | ||||
PTGS2 | Prostaglandin G/H synthase 2. (604 aa) | ||||
FABP4 | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) | ||||
FABP5 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (235 aa) | ||||
ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) | ||||
GPX7 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (317 aa) | ||||
FABP3 | Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. (133 aa) | ||||
GPX1 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa) | ||||
GPX3 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa) | ||||
ACSL1 | Acyl-CoA synthetase long chain family member 1. (771 aa) | ||||
MMP9 | Matrix metalloproteinase-9. (708 aa) | ||||
MYH1 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1956 aa) | ||||
UCP3 | Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa) | ||||
ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) | ||||
ACSL3 | Acyl-CoA synthetase long chain family member 3. (729 aa) | ||||
ALDH3A2 | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. (578 aa) | ||||
AHSG | Alpha-2-HS-glycoprotein. (394 aa) | ||||
GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa) | ||||
SERPINA3-2 | SERPIN domain-containing protein; Belongs to the serpin family. (473 aa) | ||||
ACSL4 | Acyl-CoA synthetase long chain family member 4. (711 aa) | ||||
MFN2 | Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) | ||||
RXRG | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa) | ||||
TECR | S5A_REDUCTASE domain-containing protein. (528 aa) | ||||
NR4A3 | Nuclear receptor subfamily 4 group A member 3 isoform b. (643 aa) | ||||
GGT5 | Gamma-glutamyltransferase 5. (639 aa) | ||||
PLIN5 | Perilipin 5. (736 aa) | ||||
DEPDC1B | DEP domain containing 1B. (725 aa) | ||||
COL4A1 | Collagen IV NC1 domain-containing protein. (461 aa) | ||||
APOC3 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa) | ||||
PLIN1 | Uncharacterized protein. (578 aa) | ||||
CBR4 | Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa) | ||||
ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) | ||||
SLC27A4 | Solute carrier family 27 member 4. (673 aa) | ||||
APOA2 | Apolipoprotein A-II preproprotein. (100 aa) | ||||
PLIN2 | Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family. (459 aa) |