STRINGSTRING
MIXL1 MIXL1 GATA4 GATA4 PAX2 PAX2 CTNNB1 CTNNB1 PAX6 PAX6 NKX2-1 NKX2-1 MYF5 MYF5 RAG2 RAG2 RUNX2 RUNX2 KLF4 KLF4 MYF6 MYF6 MYC MYC POU5F1 POU5F1 ETV2 ETV2 IGF1R IGF1R OTX2 OTX2 PRDM14 PRDM14 TBX5 TBX5 MYOD1 MYOD1 NEUROG1 NEUROG1 FGF10 FGF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MIXL1Mix paired-like homeobox. (237 aa)
GATA4Transcription factor GATA-4 isoform 2. (442 aa)
PAX2Paired box 2. (416 aa)
CTNNB1Catenin beta 1. (808 aa)
PAX6Paired box 6. (498 aa)
NKX2-1NK2 homeobox 1. (399 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
RAG2V(D)J recombination activating protein 2. (527 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
KLF4Kruppel-like factor 4 isoform b. (510 aa)
MYF6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (249 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
ETV2ETS variant 2. (242 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
PRDM14PR/SET domain 14. (571 aa)
TBX5T-box transcription factor 5. (535 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
NEUROG1Neurogenin 1. (246 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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